Evidence map›Paper›PMID 29581302›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

New tRNA contacts facilitate ligand binding in a

Anna V Sherwood, Jane K Frandsen, Frank J Grundy, Tina M Henkin

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. ARNA (New York, N.Y.) · 2026
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  12. On a stake-out:Non-coding RNA research · 2019
    Review
  13. Article
  14. Regulation of Bacterial Gene Expression by Transcription Attenuation.Microbiology and molecular biology reviews : MMBR · 2019
    Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anna V SherwoodMolecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210.
Jane K FrandsenCenter for RNA Biology, The Ohio State University, Columbus, OH 43210.
Frank J GrundyCenter for RNA Biology, The Ohio State University, Columbus, OH 43210.
Tina M HenkinMolecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210; henkin.3@osu.edu.
The Ohio State University · US

Funding

REGULATION OF BACILLUS SUBTILIS TRNA SYNTHETASE GENESR01GM047823 · NIGMS · OHIO STATE UNIVERSITY · PI HENKIN, TINA M. · 1994 to 2019
$4.8M
Cellular, molecular, and biochemical sciences training grantT32GM086252 · NIGMS · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH, MUSIER-FORSYTH, KARIN M · 2011 to 2020
$2.0M
A Systems Biology Approach for Targeted Drug Discovery for LeishmaniasisR21AI127582 · NIAID · OHIO STATE UNIVERSITY · PI IBBA, MICHAEL, SATOSKAR, ABHAY R · 2017 to 2018
$401k
NIAID NIH HHS R21 AI127582NIGMS NIH HHS R01 GM047823NIGMS NIH HHS T32 GM086252
6 · The paper itself

Abstract

T box riboswitches are RNA regulatory elements widely used by organisms in the phyla Firmicutes and Actinobacteria to regulate expression of amino acid-related genes. Expression of T box family genes is down-regulated by transcription attenuation or inhibition of translation initiation in response to increased charging of the cognate tRNA. Three direct contacts with tRNA have been described; however, one of these contacts is absent in a subclass of T box RNAs and the roles of several structural domains conserved in most T box RNAs are unknown. In this study, structural elements of a

Indexed as

Regulatory Elements, TranscriptionalRiboswitchGene Expression Regulation, BacterialIsoleucine-tRNA LigaseModels, MolecularMycobacterium smegmatisNucleic Acid ConformationRNA, BacterialRNA, TransferIsoleucine-tRNA LigaseRiboswitchRNA, BacterialRNA, TransferpseudoknotregulationS-turnT box riboswitchtRNA

Identifiers

PMID29581302
PMCPMC5899468
OpenAlexW2789948184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.