Evidence map›Paper›PMID 29581265›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.

Changfan Lin, Deniz Top, Craig C Manahan, Michael W Young, Brian R Crane

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
12.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. The Quantum Environment in Cryptochrome Enhances Light Absorption of FAD.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Elucidation of a distinct photoreduction pathway in class IIProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Dynamics and mechanism of DNA repair by a bifunctional cryptochrome.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Loss of functionaliScience · 2024
    Article
  13. Review
  14. A structural decryption of cryptochromes.Frontiers in chemistry · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Changfan LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Deniz TopLaboratory of Genetics, The Rockefeller University, New York, NY 10065.
Craig C ManahanDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Michael W YoungLaboratory of Genetics, The Rockefeller University, New York, NY 10065.
Brian R CraneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853; bc69@cornell.edu.
Cornell University · USRockefeller University · US

Funding

Molecular Mechanisms of Signal Transduction Involving Light, Redox and Transmembrane ComplexesR35GM122535 · NIGMS · CORNELL UNIVERSITY · PI BRIAN R CRANE · 2017 to 2026
$7.1M
Molecular and Cellular Studies of Circadian RhythmsR37GM054339 · NIGMS · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 2009 to 2018
$3.8M
MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMSR01GM054339 · NIGMS · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 1997 to 2008
$3.2M
Structure and Function of Circadian Clock Light SensorsR01GM079679 · NIGMS · CORNELL UNIVERSITY · PI CRANE, BRIAN R · 2007 to 2016
$3.1M
NIGMS NIH HHS R01 GM054339NIGMS NIH HHS R01 GM079679NIGMS NIH HHS R35 GM122535NIGMS NIH HHS R37 GM054339
6 · The paper itself

Abstract

Cryptochromes (CRYs) entrain the circadian clocks of plants and animals to light. Irradiation of the

Indexed as

Circadian ClocksAmino Acid MotifsAmino Acid SubstitutionAnimalsCryptochromesDinitrocresolsDrosophilaDrosophila ProteinsEye ProteinsLightOxidation-ReductionTryptophan4,6-dinitro-o-cresolcry protein, DrosophilaCryptochromesDinitrocresolsDrosophila ProteinsEye Proteinstim protein, DrosophilaTryptophanelectron transferlight sensorredox potentialsignal transductiontryptophan

Identifiers

PMID29581265
PMCPMC5899454
OpenAlexW2791876679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.