Evidence map›Paper›PMID 29581195›Full record

ArticleInfection and immunity2018

Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets.

Olga Yakovenko, Jamie Nunez, Barbara Bensing, Hai Yu, Jonathan Mount, Jie Zeng, Jasmine Hawkins, Xi Chen, Paul M Sullam, Wendy Thomas

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Materials today. Bio · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. The Role of Platelets in Infective Endocarditis.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
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  15. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Olga YakovenkoDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Jamie NunezDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Barbara BensingSan Francisco VA Medical Center, San Francisco, California, USA.
Hai YuDepartment of Chemistry, University of California, Davis, California, USA.
Jonathan MountDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Jie ZengDepartment of Chemistry, University of California, Davis, California, USA.
Jasmine HawkinsDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Xi ChenDepartment of Chemistry, University of California, Davis, California, USA.
Paul M SullamSan Francisco VA Medical Center, San Francisco, California, USA paul.sullam@ucsf.edu wendyt@uw.edu.
Wendy ThomasDepartment of Bioengineering, University of Washington, Seattle, Washington, USA paul.sullam@ucsf.edu wendyt@uw.edu.ORCID https://orcid.org/0000-0001-8602-0819
University of Washington · USSan Francisco VA Medical Center · USUniversity of California, Davis · USHenan Institute of Science and Technology · CN

Funding

Lung Immunopathology Training Stipend SupplementT32HL007517 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKACS, NICHOLAS W · 1985 to 2022
$6.1M
STREPTOCOCCAL PLATELET BINDING AND ENDOCARDITISR01AI041513 · NIAID · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI SULLAM, PAUL M. · 1997 to 2019
$5.6M
Mechanisms for ligand binding by serine-rich adhesins of Gram-positive pathogensR01AI106987 · NIAID · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI IVERSON, T M, SULLAM, PAUL M. · 2014 to 2018
$3.4M
Diversity Action Plan: UW GenOM ProjectR25HG007153 · NHGRI · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2020
$2.3M
NHGRI NIH HHS R25 HG007153NHLBI NIH HHS T32 HL007517NIAID NIH HHS R01 AI041513NIAID NIH HHS R01 AI106987
6 · The paper itself

Abstract

The binding of bacteria to platelets is thought to be a central event in the pathogenesis of infective endocarditis. The serine-rich repeat (SRR) glycoproteins of viridans group streptococci have been shown to mediate platelet binding

Indexed as

Adhesins, BacterialAmino Acid SequenceBacterial AdhesionBiotinylationBlood PlateletsHumansSerineStreptococcus gordoniiAdhesins, BacterialSerineadhesinsbiomechanicsbloodstream infectionsinfective endocarditisplateletsshear stressStreptococcus

Identifiers

PMID29581195
PMCPMC5964516
OpenAlexW2795065567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.