Evidence map›Paper›PMID 29581121›Full record

ArticleAntimicrobial agents and chemotherapy2018

Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection.

Chia-Ling Chen, Miao-Huei Cheng, Chih-Feng Kuo, Yi-Lin Cheng, Ming-Han Li, Chih-Peng Chang, Jiunn-Jong Wu, Robert Anderson, Shuying Wang, Pei-Jane Tsai and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. First Report ofMicroorganisms · 2025
    Article
  2. Article
  3. Rare disease-based scientific annotation knowledge graph.Frontiers in artificial intelligence · 2022
    Article
  4. Article
  5. Playing With Fire: Proinflammatory Virulence Mechanisms of Group AFrontiers in cellular and infection microbiology · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Chia-Ling Chen *School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Miao-Huei Cheng *Department of Nursing, I-Shou University, Kaohsiung, Taiwan.
Chih-Feng KuoDepartment of Nursing, I-Shou University, Kaohsiung, Taiwan.
Yi-Lin ChengDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ming-Han LiDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chih-Peng ChangDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jiunn-Jong WuCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Robert AndersonCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Shuying WangDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Pei-Jane TsaiCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Ching-Chuan LiuCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Yee-Shin LinDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan yslin1@mail.ncku.edu.tw.
National Cheng Kung University · TWI-Shou University · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group A

Indexed as

AnimalsDextromethorphanGlycogen Synthase Kinase 3HumansInflammationMiceMice, Inbred BALB CNF-kappa BNitric Oxide Synthase Type IIOnium CompoundsOxidation-ReductionPhosphorylationRAW 264.7 CellsReactive Oxygen SpeciesSignal TransductionStreptococcal InfectionsDextromethorphandiphenyleneiodoniumGlycogen Synthase Kinase 3NF-kappa BNitric Oxide Synthase Type IIOnium CompoundsReactive Oxygen Speciesdextromethorphangroup A Streptococcusinflammation

Identifiers

PMID29581121
PMCPMC5971618
OpenAlexW2794769072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.