Evidence map›Paper›PMID 29581113›Full record

ArticleAntimicrobial agents and chemotherapy2018

Chemotherapy with Phage Lysins Reduces Pneumococcal Colonization of the Respiratory Tract.

Bruno Corsini, Roberto Díez-Martínez, Leire Aguinagalde, Fernando González-Camacho, Esther García-Fernández, Patricia Letrado, Pedro García, Jose Yuste

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The applications of animal models in phage therapy: An update.Human vaccines & immunotherapeutics · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. A New Phage Lysin Isolated from the Oral Microbiome TargetingPharmaceuticals (Basel, Switzerland) · 2020
    Article
  10. Review
  11. Article
  12. Antimicrobial resistance in nephrology.Nature reviews. Nephrology · 2019
    Review
  13. Article
  14. Synergy Between Two Chimeric Lysins to KillFrontiers in microbiology · 2019
    Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bruno CorsiniCentro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain.
Roberto Díez-MartínezCentro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Leire AguinagaldeCentro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain.
Fernando González-CamachoCentro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain.
Esther García-FernándezCentro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Patricia LetradoCentro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Pedro GarcíaCentro de Investigaciones Biológicas, CSIC, Madrid, Spain pgarcia@cib.csic.es jyuste@isciii.es.
Jose YusteCentro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain pgarcia@cib.csic.es jyuste@isciii.es.ORCID 0000-0001-7996-0837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteriophage-borne lytic enzymes, also named lysins or enzybiotics, are efficient agents for the killing of bacterial pathogens. The colonization of the respiratory tract by

Indexed as

AnimalsAnti-Bacterial AgentsHumansMiceNasopharyngeal DiseasesPneumococcal InfectionsRespiratory SystemStreptococcus pneumoniaeAnti-Bacterial Agentsmouse modelnasopharyngeal colonizationphage lysinspneumococcus

Identifiers

PMID29581113
PMCPMC5971604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.