ArticleReproductive toxicology (Elmsford, N.Y.)2018
Methylmercury alters proliferation, migration, and antioxidant capacity in human HTR8/SV-neo trophoblast cells.
Article in Reproductive toxicology (Elmsford, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Antioxidant Supplementation Alleviates Mercury-Induced Cytotoxicity and Restores the Implantation-Related Functions of Primary Human Endometrial Cells.International journal of molecular sciences · 2023Article
- Cellular Conditions Responsible for Methylmercury-Mediated Neurotoxicity.International journal of molecular sciences · 2022Review
- Assessment of the effects of organic vs. inorganic arsenic and mercury inCurrent research in toxicology · 2022Article
- Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals.Reproductive toxicology (Elmsford, N.Y.) · 2022Review
- The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells.Frontiers in toxicology · 2022Article
- Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity.Archives of toxicology · 2021Review
- Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell Line HTR-8/SVneo.International journal of molecular sciences · 2021Article
- Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta.Archives of toxicology · 2020Article
- Mild steel and stainless steel welding fumes elicit pro-inflammatory and pro-oxidant effects in first trimester trophoblast cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- Prenatal Environment That Affects Neuronal Migration.Frontiers in cell and developmental biology · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Methylmercury, a potent neurotoxin, is able to pass through the placenta, but its effects on the placenta itself have not been elucidated. Using an immortalized human trophoblast cell line, HTR8/SV-neo, we assessed the in vitro toxicity of methylmercury. We found that 1 μg/mL methylmercury decreased viability, proliferation, and migration; and it had effects on antioxidant genes similar to those seen in neural cells. However, methylmercury led to decreased expression of superoxide dismutase 1 and increased expression of surfactant protein D. HTR cells treated 0.01 or 0.1 μg/mL methylmercury had increased migration rates along with decreased expression of an adhesion gene, cadherin 3, suggesting that low doses of methylmercury promote migration in HTR cells. Our results indicate that trophoblast cells react differently to methylmercury relative to neural cell lines, and thus investigation of methylmercury toxicity in placental cells is needed to understand the effects of this heavy metal on the placenta.
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Registered trials
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