Evidence map›Paper›PMID 29580944›Full record

ArticleArchives of biochemistry and biophysics2018

Inhibition of anthrax lethal factor by ssDNA aptamers.

Mieke Lahousse, Hae-Chul Park, Sang-Choon Lee, Na-Reum Ha, In-Pil Jung, Sara R Schlesinger, Kaylin Shackelford, Moon-Young Yoon, Sung-Kun Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Aptamers: An Emerging Tool for Diagnosis and Therapeutics in Tuberculosis.Frontiers in cellular and infection microbiology · 2021
    Review
  5. Review
  6. Novel Detection of Nasty Bugs, Prevention Is Better than Cure.International journal of molecular sciences · 2020
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Mieke LahousseThe Institute of Biomedical Studies, and the Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798-7348, USA.
Hae-Chul ParkDepartment of Chemistry, Hanyang University, Seoul, 133-791, Republic of Korea.
Sang-Choon LeeDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Na-Reum HaDepartment of Chemistry, Hanyang University, Seoul, 133-791, Republic of Korea.
In-Pil JungDepartment of Chemistry, Hanyang University, Seoul, 133-791, Republic of Korea.
Sara R SchlesingerThe Institute of Biomedical Studies, and the Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798-7348, USA.
Kaylin ShackelfordDepartment of Natural Sciences, Northeastern State University, Tahlequah, OK 74464, USA.
Moon-Young YoonDepartment of Chemistry, Hanyang University, Seoul, 133-791, Republic of Korea.
Sung-Kun KimDepartment of Natural Sciences, Northeastern State University, Tahlequah, OK 74464, USA. Electronic address: kim03@nsuok.edu.
Hanyang University · KRBaylor University · USNortheastern State University · USGeorgia State University · US

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DARRIN R. AKINS · 2012 to 2026
$60.2M
NIGMS NIH HHS P20 GM103447
6 · The paper itself

Abstract

Anthrax is caused by Bacillus anthracis, a bacterium that is able to secrete the toxins protective antigen, edema factor and lethal factor. Due to the high level of secretion from the bacteria and its severe virulence, lethal factor (LF) has been sought as a biomarker for detecting bacterial infection and as an effective target to neutralize toxicity. In this study, we found three aptamers, and binding affinity was determined by fluorescently labeled aptamers. One of the aptamers exhibited high affinity, with a K

Indexed as

AnimalsAntigens, BacterialAptamers, NucleotideBacillus anthracisBacterial ToxinsDNA, Single-StrandedEnzyme-Linked Immunosorbent AssayMAP Kinase Kinase 1MiceProtein BindingProteolysisRAW 264.7 CellsSELEX Aptamer Techniqueanthrax toxinAntigens, BacterialAptamers, NucleotideBacterial ToxinsDNA, Single-StrandedMAP2K1 protein, humanMAP Kinase Kinase 1

Identifiers

PMID29580944
PMCPMC5916030
OpenAlexW2790415023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.