ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Altered functional activity in bipolar disorder: A comprehensive review from a large-scale network perspective.Brain and behavior · 2021Pooled it
- Intrinsic functional neurocircuitry associated with treatment response to transdiagnostic CBT in bipolar disorder with anxiety.Journal of affective disorders · 2018Trial
- Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls.Molecular psychiatry · 2026Article
- Shifts in attentional demand are accompanied by sex-specific patterns of insula-frontal cortical interactions in mice.NeuroImage · 2026Article
- Severity-dependent fronto-cingulate network compensation of immune-dependent caudate-insula dysconnectivity in bipolar II depression.Research square · 2026Article
- Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.Bipolar disorders · 2025Article
- Distinct connectivity patterns in bipolar and unipolar depression: a functional connectivity multivariate pattern analysis study.BMC neuroscience · 2024Article
- Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale.World journal of clinical cases · 2023Article
- Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder.BMC psychiatry · 2023Article
- Article
- Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder.Brain and behavior · 2023Article
- Non-traditional cognitive brain network involvement in insulo-Sylvian gliomas: a case series study and clinical experience using Quicktome.Chinese neurosurgical journal · 2023Article
- Neuroimaging Correlates of Treatment Response to Transcranial Magnetic Stimulation in Bipolar Depression: A Systematic Review.Brain sciences · 2023Review
- Comparing the test-retest reliability of resting-state functional magnetic resonance imaging metrics across single band and multiband acquisitions in the context of healthy aging.Human brain mapping · 2023Article
- Emotion regulation in bipolar disorder type-I: multivariate analysis of fMRI data.International journal of bipolar disorders · 2023Article
- Neuromodulation for treatment-resistant depression: Functional network targets contributing to antidepressive outcomes.Frontiers in human neuroscience · 2023Review
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Evaluating the Alterations Induced by Virtual Reality in Cerebral Small-World Networks Using Graph Theory Analysis with Electroencephalography.Brain sciences · 2022Article
- Depression mediates the association between insula-frontal functional connectivity and social interaction anxiety.Human brain mapping · 2022Article
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9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPatients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment.
methodsResting-state functional magnetic resonance imaging data were collected from 98 subjects (35 unipolar, 24 bipolar, and 39 healthy control subjects). Pearson correlations were computed between bilateral insula seed regions and a priori defined target regions from the default mode network, salience network, and ECN. After r-to-z transformation, a one-way multivariate analysis of covariance was conducted to identify significant differences in connectivity between groups. Post hoc pairwise comparisons were conducted and Bonferroni corrections were applied. Receiver-operating characteristics were computed to assess diagnostic sensitivity.
resultsPatients with bipolar depression evidenced significantly altered right anterior insula functional connectivity with the inferior parietal lobule of the ECN relative to patients with unipolar depression and control subjects. Right anterior insula-inferior parietal lobule connectivity significantly discriminated patients with bipolar depression.
conclusionsImpaired functional connectivity between the anterior insula and the inferior parietal lobule of the ECN distinguishes patients with bipolar depression from those with unipolar depression and healthy control subjects. This finding highlights a pathophysiological mechanism with potential as a therapeutic target and a clinical biomarker for bipolar disorder, exhibiting reasonable sensitivity and specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.