Evidence map›Paper›PMID 29580740›Full record

ArticleSchizophrenia research2018

Negative voice-content as a full mediator of a relation between childhood adversity and distress ensuing from hearing voices.

Cherise Rosen, Simon McCarthy-Jones, Nev Jones, Kayla A Chase, Rajiv P Sharma

Abstract read
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  11. Remission of schizophrenia after an EMDR session.European journal of psychotraumatology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Cherise RosenDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: ccrosen@uic.edu.
Simon McCarthy-JonesDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Nev JonesDepartment of Mental Health Law & Policy, University of South Florida, Florida, USA.
Kayla A ChaseDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Rajiv P SharmaDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
University of Illinois Chicago · USTrinity College Dublin · IEUniversity of South Florida · US

Funding

The H3K9 HISTONE SWITCH; 'LEVELS' IN SCHIZOPHRENIA BLOOD AND BRAINR01MH094358 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHARMA, RAJIV PANDIT · 2012 to 2016
$2.3M
NIMH NIH HHS R01 MH094358
6 · The paper itself

Abstract

A key predictor of whether or not an individual who hears voices (auditory verbal hallucinations; AVH) meets criteria for a psychiatric diagnosis is the level of negative content of the voices (e.g., threats, criticism, abuse). Yet the factors that contribute to negative voice-content are still not well understood. This study aimed to test the hypotheses that levels of childhood adversity would predict levels of negative voice-content, and that negative voice-content would partially mediate a relation between childhood adversity and voice-related distress. These hypotheses were tested in a clinical sample of 61 patients with formally diagnosed psychotic disorders (48 schizophrenia, 13 bipolar). We found evidence consistent with negative voice-content fully (not partially) mediating the relation between childhood adversity and voice-related distress. Although bivariate analyses found depression to be associated with both negative voice-content and voice-related distress, we found no evidence of an indirect effect of childhood adversity on either negative voice-content or voice-related distress via depression. Alternative study designs are now needed to test if our findings are replicable and causal. Should they be, it will be necessary for psychological therapies to devise ways to reduce negative voice-content itself, rather than just changing beliefs about voices. A number of techniques are discussed (Avatar Therapy, Compassion Focused Therapy, voice-dialogue) that already show promise for this.

Indexed as

AdultAdult Survivors of Child Adverse EventsAgedBipolar DisorderFemaleHallucinationsHumansMaleMiddle AgedSchizophreniaSchizophrenic PsychologyStress, PsychologicalYoung AdultCognitive modelTraumaVoice-hearing

Identifiers

PMID29580740
PMCPMC6151289
OpenAlexW2789468185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.