ArticleKidney international2018
Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing.
Article in Kidney international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Injury-induced paracrine effects on the podocyte's transcriptome.American journal of physiology. Renal physiology · 2026Article
- Podocytes in health and glomerular disease.Frontiers in cell and developmental biology · 2025Review
- Hold the salt for kidney regeneration.The Journal of clinical investigation · 2024Article
- Central role of podocytes in mediating cellular cross talk in glomerular health and disease.American journal of physiology. Renal physiology · 2024Review
- Cells of the renin lineage promote kidney regeneration post-release of ureteral obstruction in neonatal mice.Acta physiologica (Oxford, England) · 2023Article
- Mechanisms of podocyte injury and implications for diabetic nephropathy.Clinical science (London, England : 1979) · 2022Article
- Potential renal stem/progenitor cells identified by in vivo lineage tracing.American journal of physiology. Renal physiology · 2022Review
- Telomerase is required for glomerular renewal in kidneys of adult mice.NPJ Regenerative medicine · 2022Article
- Determining lineage relationships in kidney development and disease.Nature reviews. Nephrology · 2022Review
- Cell Hypertrophy: A "Biophysical Roadblock" to Reversing Kidney Injury.Frontiers in cell and developmental biology · 2022Article
- Recent advances in lineage tracing for the kidney.Kidney international · 2021Review
- Renal subcapsular delivery of PGEiScience · 2021Article
- Global transcriptomic changes occur in aged mouse podocytes.Kidney international · 2020Article
- mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.JCI insight · 2019Article
- Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate toward the adult podocyte fate.Kidney international · 2019Article
- How can juxtaglomerular renin-producing cells support the integrity of glomerular endothelial cells?Pflugers Archiv : European journal of physiology · 2019Article
- Urinary Renin in Patients and Mice With Diabetic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry.JCI insight · 2019Article
- Organoid single cell profiling identifies a transcriptional signature of glomerular disease.JCI insight · 2019Article
- Pathology identifies glomerular treatment targets in diabetic nephropathy.Kidney research and clinical practice · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Understanding of cellular transdifferentiation is limited by the technical inability to track multiple lineages in vivo. To overcome this we developed a new tool to simultaneously fate map two distinct cell types in the kidney, and genetically test whether cells of renin lineage (CoRL) can transdifferentiate to a podocyte fate. Ren1cCreER/tdTomato/Nphs1-FLPo/FRT-EGFP mice (CoRL-PODO mice) were generated by crossing Ren1c-CreER/tdTomato CoRL reporter mice with Nphs1-FLPo/FRT-EGFP podocyte reporter mice. Following tamoxifen administration in these animals, CoRL were labeled with red fluorescence (tdTomato) and co-localized with renin. Podocytes were labeled green (enhanced green fluorescent protein) and co-localized with nephrin. Following podocyte loss by nephrotoxic antibody and subsequent enalapril-enhanced partial replacement, tdTomato-EGFP-labeled CoRL were detected as yellow-colored cells in a subset of glomerular tufts, without the use of antibodies. Co-localization with podocin indicated that these cells are podocytes, derived from CoRL origin. Thus, our novel study shows that two distinct cell types can be simultaneously labeled in the mouse kidney and provide strong genetic evidence in vivo that lost podocytes can be replaced in part by CoRL.
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