Evidence map›Paper›PMID 29580384›Full record

ArticleeLife2018

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.

Lisa Landskron, Victoria Steinmann, Francois Bonnay, Thomas R Burkard, Jonas Steinmann, Ilka Reichardt, Heike Harzer, Anne-Sophie Laurenson, Heinrich Reichert, Jürgen A Knoblich

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. RNA-binding is the essential biological function of thebioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Principles and mechanisms of asymmetric cell division.Development (Cambridge, England) · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. A gene expression atlas of embryonic neurogenesis inDevelopment (Cambridge, England) · 2019
    Article
  19. The emerging role of lncRNAs in the regulation of cancer stem cells.Cellular oncology (Dordrecht, Netherlands) · 2018
    Review
  20. Article
4 · The record

Corrections and comments

  • Commented on by
    2018
5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lisa LandskronIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0003-0405-2046
Victoria SteinmannIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Francois BonnayIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Thomas R BurkardIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Jonas SteinmannIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Ilka ReichardtIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Heike HarzerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Anne-Sophie LaurensonBiozentrum, University of Basel, Basel, Switzerland.
Heinrich ReichertBiozentrum, University of Basel, Basel, Switzerland.
Jürgen A KnoblichIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0002-6751-3404
Institute of Molecular Biotechnology · ATUniversity of Basel · CH

Funding

Austrian Science Fund FWF Z_153_B09
6 · The paper itself

Abstract

Tumor cells display features that are not found in healthy cells. How they become immortal and how their specific features can be exploited to combat tumorigenesis are key questions in tumor biology. Here we describe the long non-coding RNA cherub that is critically required for the development of brain tumors in

Indexed as

Cell Transformation, NeoplasticAnimalsBrain NeoplasmsCell ProliferationCells, CulturedDisease Models, AnimalDrosophilaDrosophila ProteinsNeoplastic Stem CellsNeural Stem CellsRNA-Binding ProteinsRNA, Long NoncodingDrosophila ProteinsRNA-Binding ProteinsRNA, Long Noncodingstau protein, DrosophilaSyp protein, Drosophilacancer biologydevelopmental biologyD. melanogasterlncRNAneural stem cellsneuroblastsstem cellstumorigenesis

Identifiers

PMID29580384
PMCPMC5871330
OpenAlexW2794842943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.