ArticleeLife2018
Origin and evolution of the nuclear auxin response system.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it, 259 citations in OpenAlex.
- Early "Rootprints" of Plant Terrestrialization: Selaginella Root Development Sheds Light on Root Evolution in Vascular Plants.Frontiers in plant science · 2021Pooled it
- AUXIN RESPONSE FACTORs: from transcription factors to auxin effectors.The New phytologist · 2026Review
- The evolutionary origins of streptophyte multicellularity.The New phytologist · 2026Review
- The Spirogyra pratensis genome illuminates the evolution of developmental programs and spiral chloroplast biology.The Plant cell · 2026Article
- Pan-plantae aquaporin evolution: insights intoHorticulture research · 2026Article
- Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies.FEBS open bio · 2026Article
- Laser ablation microscopy reveals apical notch, apical dominance, and meristem regeneration dynamics inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mutational analyses of an instability domain reveal its conserved role in the regulation of class-B ARF levels inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolutionary shifts in plant adaptation mediated by phytohormones.Plant communications · 2026Review
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- AUXIN RESPONSE FACTOR thermostability.Nature communications · 2026Article
- Diversification of functional requirements for proteolysis of auxin response factors.Nature communications · 2026Article
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- miRNA-targeted auxin nuclear signalling elements orchestrate flower fate and drought response in yellow lupine.Scientific reports · 2025Article
- NGATHA carpel development genes evolved in the common ancestor of seed plants.The Plant journal : for cell and molecular biology · 2025Article
- N-Terminal Metal-Binding Domain of Arabidopsis IBR5 Is Important for Its in Planta Functions.International journal of molecular sciences · 2025Article
- The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens.Journal of experimental botany · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Expression analyses of sweet cherry AUX/IAAs and involvements of PavAUX/IAA9/11 in regulating fruitlet abscission.Plant cell reports · 2025Article
- Algal origins of core land plant stress response subnetworks.The Plant journal : for cell and molecular biology · 2025Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small signaling molecule auxin controls numerous developmental processes in land plants, acting mostly by regulating gene expression. Auxin response proteins are represented by large families of diverse functions, but neither their origin nor their evolution is understood. Here, we use a deep phylogenomics approach to reconstruct both the origin and the evolutionary trajectory of all nuclear auxin response protein families. We found that, while all subdomains are ancient, a complete auxin response mechanism is limited to land plants. Functional phylogenomics predicts defined steps in the evolution of response system properties, and comparative transcriptomics across six ancient lineages revealed how these innovations shaped a sophisticated response mechanism. Genetic analysis in a basal land plant revealed unexpected contributions of ancient non-canonical proteins in auxin response as well as auxin-unrelated function of core transcription factors. Our study provides a functional evolutionary framework for understanding diverse functions of the auxin signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.