Evidence map›Paper›PMID 29580379›Full record

ArticleeLife2018

Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.

Adam J Reid, Arthur M Talman, Hayley M Bennett, Ana R Gomes, Mandy J Sanders, Christopher J R Illingworth, Oliver Billker, Matthew Berriman, Mara Kn Lawniczak

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed.

  1. Review
  2. mSphere · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Evolutionary Trajectory ofBiomedicines · 2025
    Review
  9. Review
  10. Article
  11. Malaria: past, present, and future.Signal transduction and targeted therapy · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam J Reid *Malaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.
Arthur M Talman *Malaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.
Hayley M Bennett *Malaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.
Ana R GomesMalaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.
Mandy J SandersMalaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.
Christopher J R IllingworthDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-0030-2784
Oliver BillkerMalaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.ORCID 0000-0003-1716-168X
Matthew BerrimanMalaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.ORCID 0000-0002-9581-0377
Mara Kn LawniczakMalaria Programme, Wellcome Sanger Institute, Cambridge, United Kingdom.ORCID 0000-0002-3006-2080

Funding

Medical Research Council G1100339Wellcome TrustWellcome Trust 01239/Z/13/ZWellcome Trust WT098051
6 · The paper itself

Abstract

Single-cell RNA-sequencing is revolutionising our understanding of seemingly homogeneous cell populations but has not yet been widely applied to single-celled organisms. Transcriptional variation in unicellular malaria parasites from the

Indexed as

Gene Expression ProfilingGenetic VariationSequence Analysis, RNASingle-Cell AnalysisAnimalsHumansPlasmodiumRodentiacell biologyevolutionary biologygenomicsmalariaP. falciparumscRNAseqtransmission

Identifiers

PMID29580379
PMCPMC5871331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.