ArticleThe Journal of general virology2018
Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids.
Article in The Journal of general virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Maternal chronic wasting disease infection restricts fetal head size in white-tailed deer (Prion · 2026Article
- Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties.PLoS pathogens · 2026Article
- The Strain Properties of Korean and North American Chronic Wasting Disease Prions Are Indistinguishable.The Journal of infectious diseases · 2025Article
- Scrapie versus Chronic Wasting Disease in White-Tailed Deer.Emerging infectious diseases · 2024Article
- Prion Seeding Activity in Plant Tissues Detected by RT-QuIC.Pathogens (Basel, Switzerland) · 2024Article
- Ticks harbor and excrete chronic wasting disease prions.Scientific reports · 2023Article
- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland.Emerging infectious diseases · 2023Article
- Tissue-specific biochemical differences between chronic wasting disease prions isolated from free-ranging white-tailed deer (Odocoileus virginianus).The Journal of biological chemistry · 2022Article
- Review
- Modeling the Impact of Climate Change on Cervid Chronic Wasting Disease in Semi-Arid South Texas.Frontiers in epidemiology · 2022Article
- Article
- Host prion protein expression levels impact prion tropism for the spleen.PLoS pathogens · 2020Article
- Very low oral exposure to prions of brain or saliva origin can transmit chronic wasting disease.PloS one · 2020Article
- Progression of chronic wasting disease in white-tailed deer analyzed by serial biopsy RT-QuIC and immunohistochemistry.PloS one · 2020Article
- Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids.Scientific reports · 2019Article
- Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions.Journal of clinical microbiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The prevalence, host range and geographical bounds of chronic wasting disease (CWD), the prion disease of cervids, are expanding. Horizontal transmission likely contributes the majority of new CWD cases, but the mechanism by which prions are transmitted among CWD-affected cervids remains unclear. To address the extent to which prion amplification in peripheral tissues contributes to contagious transmission, we assessed the prion levels in central nervous and lymphoreticular system tissues in white-tailed deer (Odocoileus virginianus), red deer (Cervus elaphus elaphus) and elk (Cervus canadensis). Using real-time quaking-induced conversion, cervid prion cell assay and transgenic mouse bioassay, we found that the retropharyngeal lymph nodes of red deer, white-tailed deer and elk contained similar prion titres to brain from the same individuals. We propose that marked lymphotropism is essential for the horizontal transmission of prion diseases and postulate that shed CWD prions are produced in the periphery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.