Evidence map›Paper›PMID 29580291›Full record

ArticleGenome biology2018

Pulling the genome in opposite directions to dissect gene networks.

Charles A Gersbach, Rodolphe Barrangou

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Charles A GersbachDepartment of Biomedical Engineering, Center for Genomic and Computational Biology, Duke University, Durham, NC, USA. charles.gersbach@duke.edu.
Rodolphe BarrangouDepartment of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, 27695, USA. rbarran@ncsu.edu.

Funding

Decoding and Reprogramming the Corticosteroid Transcriptional Regulatory NetworkU01HG007900 · NHGRI · DUKE UNIVERSITY · PI REDDY, TIMOTHY E · 2015 to 2017
$5.9M
Regulatory Mechanisms of CD4+ T Cell DifferentiationUM1HG009428 · NHGRI · DUKE UNIVERSITY · PI CIOFANI, MARIA, CRAWFORD, GREGORY E · 2017 to 2021
$4.6M
Engineering Targeted Epigenetic Modifiers for Precise Control of Gene RegulationR01DA036865 · NIDA · DUKE UNIVERSITY · PI CRAWFORD, GREGORY E, GERSBACH, CHARLES A. · 2013 to 2017
$2.6M
In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic MiceR21DA041878 · NIDA · DUKE UNIVERSITY · PI GERSBACH, CHARLES A., WEST, ANNE ELIZABETH · 2016 to 2017
$392k
Foundation for the National Institutes of Health R01DA036865, U01HG007900, R21DA041878NHGRI NIH HHS U01 HG007900NHGRI NIH HHS UM1 HG009428NIDA NIH HHS R01 DA036865NIDA NIH HHS R21 DA041878
6 · The paper itself

Abstract

Orthogonal CRISPR-Cas systems have been integrated into combinatorial screens to decipher complex genetic relationships in two recent studies.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated Protein 9CRISPR-Cas SystemsGene Regulatory NetworksGenomeCRISPR-Associated Protein 9

Identifiers

PMID29580291
PMCPMC5870483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.