ArticleBMC microbiology2018
Foreign peptide triggers boost in pneumococcal metabolism and growth.
Article in BMC microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Regulation of PBP2x Surface Localization byPathogens (Basel, Switzerland) · 2026Article
- Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carryingMicrobiology (Reading, England) · 2025Article
- AliC and AliD of nonencapsulatedFrontiers in cellular and infection microbiology · 2025Article
- Unravelling mechanisms of bacterial recognition by Acanthamoeba: insights into microbial ecology and immune responses.Frontiers in microbiology · 2024Review
- Human Serum Supplementation Promotes Streptococcus mitis Growth and Induces Specific Transcriptomic Responses.Microbiology spectrum · 2023Article
- Diminished Pneumococcal-Specific CD4Frontiers in aging · 2021Article
- In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis.PLoS pathogens · 2019Article
- Peptide Occurring in Enterobacteriaceae TriggersFrontiers in cellular and infection microbiology · 2019Article
- Peptide Ligands of AmiA, AliA, and AliB Proteins Determine Pneumococcal Phenotype.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNonencapsulated Streptococcus pneumoniae bacteria are successful colonizers of the human nasopharynx and often possess genes aliB-like ORF 1 and 2 in place of capsule genes. AliB-like ORF 2 binds peptide FPPQSV, found in Prevotella species, resulting in enhanced colonization. How this response is mediated is so far unknown.
resultsHere we show that the peptide increases expression of genes involved in release of host carbohydrates, carbohydrate uptake and carbohydrate metabolism. In particular, the peptide increased expression of 1,5-anhydro-D-fructose reductase, a metabolic enzyme of an alternative starch and glycogen degrading pathway found in many organisms, in both transcriptomic and proteomic data. The peptide enhanced pneumococcal growth giving a competitive advantage to a strain with aliB-like ORF 2, over its mutant lacking the gene. Possession of aliB-like ORF 2 did not affect release of inflammatory cytokine CXCL8 from epithelial cells in culture and the nonencapsulated wild type strain was not able to establish disease or inflammation in an infant rat model of meningitis.
conclusionsWe propose that AliB-like ORF 2 confers an advantage in colonization by enhancing carbohydrate metabolism resulting in a boost in growth. This may explain the widespread presence of aliB-like ORF 2 in the nonencapsulated pneumococcal population in the human nasopharynx.
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Registered trials
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