Evidence map›Paper›PMID 29580170›Full record

ArticleThyroid : official journal of the American Thyroid Association2018

Comparison of Therapeutic Triiodothyronine Versus Metoprolol in the Treatment of Myocardial Infarction in Rats.

Kuo Zhang, Yi-Da Tang, Youhua Zhang, Kaie Ojamaa, Ying Li, Amandeep Singh Saini, Maria Alicia Carrillo-Sepulveda, Viswanathan Rajagopalan, A Martin Gerdes

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kuo Zhang1 Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .
Yi-Da Tang1 Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .
Youhua Zhang2 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Old Westbury, New York.
Kaie Ojamaa2 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Old Westbury, New York.
Ying Li2 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Old Westbury, New York.
Amandeep Singh Saini2 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Old Westbury, New York.
Maria Alicia Carrillo-Sepulveda2 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Old Westbury, New York.
Viswanathan Rajagopalan3 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Jonesboro, Arkansas.
A Martin Gerdes2 Department of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine , Old Westbury, New York.
New York Institute of Technology · USChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Low Thyroid function and myocardial infarctionR01HL103671 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI GERDES, ANTHONY MARTIN · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL103671
6 · The paper itself

Abstract

backgroundBeta blockers are standard therapy for myocardial infarction (MI). Preclinical studies have shown efficacy and safety of thyroid hormone (TH) treatment of cardiovascular disorders. Since THs interact with the sympathoadrenergic system, this study aimed to compare triiodothyronine (T3) and metoprolol (Met) in the treatment of rats with MI on pathophysiology and TH-adrenergic signaling.

methodsFemale Sprague-Dawley rats aged 12 weeks underwent left anterior descending coronary artery ligation (MI) or sham surgeries. T3 (5 μg/kg/day) or Met (100 mg/kg/day) was given in drinking water immediately after surgery for eight weeks. At the terminal of the experiments, the rats were subjected to morphological, functional, and molecular examination.

resultsT3 and Met significantly enhanced left ventricular contractility (left ventricular fractional shortening 21.37 ± 2.58% and 21.14 ± 3.71%, respectively) compared to untreated MI (17.88 ± 1.23%), and decreased the incidence of inducible atrial tachyarrhythmia by 87.5% and 62.5%, respectively. Although both treatments showed efficacy, T3 but not Met showed statistically significant improvements compared to MI in arrhythmia duration, left atrial diameter (T3 vs. MI 4.33 ± 0.63 vs. 5.65 ± 1.32 mm; p < 0.05), fibrosis (6.1 ± 0.6%, 6.6 ± 0.6% vs. 8.2 ± 0.7%, T3, Met vs. MI, respectively), and aortic vasorelaxation responsiveness to acetylcholine (pD2 6.97 ± 0.22, 6.83 ± 0.21 vs. 6.66 ± 0.22, T3, Met vs. MI, respectively). Quantitative polymerase chain reaction showed that T3 and Met attenuated expression of genes associated with inflammation and oxidative stress and restored expression of ion channels and contractile proteins.

conclusionThese results support comparable efficacy of T3 and Met treatments, suggesting that T3 may provide a therapeutic alternative to standard β-receptor blockade, especially for patients intolerant to treatment with β-blockers after MI.

Indexed as

AnimalsAnti-Arrhythmia AgentsArrhythmias, CardiacDisease Models, AnimalEchocardiographyElectrophysiologyFemaleFibrosisHeart AtriaHeart VentriclesHemodynamicsInflammationMetoprololMyocardial InfarctionOxidative StressRatsAnti-Arrhythmia AgentsMetoprololThyroid HormonesThyroxineTriiodothyronineheart functionmetoprololmyocardial infarctiontriiodothyronine

Identifiers

PMID29580170
PMCPMC5994663
OpenAlexW2795098668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.