ArticleTissue engineering. Part A2018
Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair.
Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 100 citations in OpenAlex.
- Biomimetic Core-Sheath GelMA/PCL Nanofibers for Enhanced Peripheral Nerve Regeneration.Polymers · 2026Article
- Biomechanical Evaluation of a Novel Sutureless Hydrogel Device for Peripheral Nerve Repair.Bioengineering (Basel, Switzerland) · 2026Article
- Bioactive Hydrogels for Spinal Cord Injury Repair: Emphasis on Gelatin and Its Derivatives.Gels (Basel, Switzerland) · 2025Review
- Gelatin-Based Hydrogels for Peripheral Nerve Regeneration: A Multifunctional Vehicle for Cellular, Molecular, and Pharmacological Therapy.Gels (Basel, Switzerland) · 2025Review
- Electrical and magnetic stimulation separately modulates the extent and direction of neurite outgrowth in an ionically conductive hydrogel.Journal of neural engineering · 2025Article
- Advances in adhesive hydrogels applied for ophthalmology: An overview focused on the treatment.Theranostics · 2025Review
- A stretchable, electroconductive tissue adhesive for the treatment of neural injury.Bioengineering & translational medicine · 2024Article
- Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications.Biomedicines · 2024Review
- Effect of Spray-Type Alginate Hydrogel Dressing on Burn Wounds.Gels (Basel, Switzerland) · 2024Article
- Dexamethasone release from hyaluronic acid microparticle and proanthocyanidin-gelatin hydrogel in sciatic tissue regeneration.Journal of materials science. Materials in medicine · 2024Article
- One-step stromal vascular fraction therapy in osteoarthritis with tropoelastin-enhanced autologous stromal vascular fraction gel.Frontiers in bioengineering and biotechnology · 2024Article
- Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality.Bioactive materials · 2023Article
- Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair.Bioactive materials · 2023Article
- Systematic Comparison of Commercial Hydrogels Revealed That a Synergy of Laminin and Strain-Stiffening Promotes Directed Migration of Neural Cells.ACS applied materials & interfaces · 2023Article
- Recent Developments in Biopolymer-Based Hydrogels for Tissue Engineering Applications.Biomolecules · 2023Review
- Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering.Cells, tissues, organs · 2023Article
- Photocrosslinkable natural polymers in tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Development of tropoelastin-functionalized anisotropic PCL scaffolds for musculoskeletal tissue engineering.Regenerative biomaterials · 2023Article
- Engineering a highly elastic bioadhesive for sealing soft and dynamic tissues.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures leads to scar tissue formation, hinders nerve regeneration, and prevents functional recovery. Fibrin-based adhesives have been widely used for nerve reconstruction, but their limited adhesive and mechanical strength and inability to promote nerve regeneration hamper their utility as a stand-alone intervention. To overcome these challenges, we engineered composite hydrogels that are neurosupportive and possess strong tissue adhesion. These composites were synthesized by photocrosslinking two naturally derived polymers, gelatin-methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA/MeTro ratio. In addition, GelMA/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue ex vivo compared to fibrin control. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation in vitro, which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA/MeTro hydrogels exhibited slower degradation in vivo compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves. Thus, GelMA/MeTro composites may be used as clinically relevant biomaterials to regenerate nerves and reduce the need for microsurgical suturing during nerve reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.