Evidence map›Paper›PMID 29580154›Full record

ReviewMolecular pain

Inhibitory G

Yevgen Yudin, Tibor Rohacs

Open access · goldAbstract readReview
In one paragraph

Review in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Targeting GCell reports. Medicine · 2026
    Article
  2. Review
  3. Review
  4. GABAMedComm · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Exploring pharmacological inhibition of GBritish journal of pharmacology · 2022
    Article
  10. 5-HT3/7 and GABANutritional neuroscience · 2022
    Article
  11. Peripheral role of glutamate in orofacial pain.Frontiers in neuroscience · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yevgen Yudin1 Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA.
Tibor Rohacs1 Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0003-3580-2575
Rutgers, The State University of New Jersey · US

Funding

Regulation of sensory TRP channels by phospholipids and G-proteinsR01NS055159 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ROHACS, TIBOR · 2007 to 2022
$5.9M
Regulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9M
Molecular mechanism of TRPV1 activationR01GM131048 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM093290NIGMS NIH HHS R01 GM131048NINDS NIH HHS R01 NS055159
6 · The paper itself

Abstract

Primary sensory neurons in the dorsal root ganglia and trigeminal ganglia are responsible for sensing mechanical and thermal stimuli, as well as detecting tissue damage. These neurons express ion channels that respond to thermal, mechanical, or chemical cues, conduct action potentials, and mediate transmitter release. These neurons also express a large number of G-protein coupled receptors, which are major transducers for extracellular signaling molecules, and their activation usually modulates the primary transduction pathways. Receptors that couple to phospholipase C via heterotrimeric G

Indexed as

AnalgesicsAnimalsGTP-Binding Protein alpha Subunits, Gi-GoHumansReceptors, G-Protein-CoupledSensory Receptor CellsSignal TransductionSomatosensory CortexAnalgesicsGTP-Binding Protein alpha Subunits, Gi-GoReceptors, G-Protein-Coupleddorsal root ganglion neuronGABAB receptorGi-coupledG-protein coupled receptoropioid receptortrigeminal ganglion neuron

Identifiers

PMID29580154
PMCPMC5882016
OpenAlexW2794802936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.