Evidence map›Paper›PMID 29580153›Full record

ArticleMolecular pain

Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ-1 subunits.

Sascha Ra Alles, Esperanza Garcia, Sridhar Balasubramanyan, Karen Jones, John R Tyson, Twinkle Joy, Terrance P Snutch, Peter A Smith

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Regulatory Action of Calcium and Calcium Channels in Pain Pathways.International journal of biological sciences · 2025
    Review
  3. Review
  4. Article
  5. Evaluation ofACS chemical neuroscience · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Neuropathic pain; what we know and what we should do about it.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sascha Ra Alles1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Esperanza Garcia1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Sridhar Balasubramanyan3 Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Karen Jones1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
John R Tyson1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Twinkle Joy3 Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Terrance P Snutch1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Peter A Smith3 Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
University of British Columbia · CAWomen and Children’s Health Research Institute · CACanada's Michael Smith Genome Sciences Centre · CA

Funding

CIHR 10677
6 · The paper itself

Abstract

Background Following peripheral nerve chronic constriction injury, the accumulation of the α2δ-1 auxiliary subunit of voltage-gated Ca

Indexed as

Synaptic TransmissionAminesAnimalsCalcium Channels, L-TypeCattleConstriction, PathologicCyclohexanecarboxylic AcidsDihydropyridinesExcitatory Postsynaptic PotentialsGabapentingamma-Aminobutyric AcidHEK293 CellsHumansHyperalgesiaMaleNitrendipine1,4-dihydropyridineAminesCalcium Channels, L-TypeCyclohexanecarboxylic AcidsDihydropyridinesGabapentingamma-Aminobutyric AcidNitrendipineProtein SubunitsAllodyniaanti-allodyniccalcium channel blockercentral sensitizationchronic constriction injurydihydropyridinegabapentinneuropathic painpharmacologysubstantia gelatinosa

Identifiers

PMID29580153
PMCPMC5882044
OpenAlexW2794975044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.