Evidence map›Paper›PMID 29580136›Full record

ReviewAnnual review of food science and technology2018

Milk Glycans and Their Interaction with the Infant-Gut Microbiota.

Nina Kirmiz, Randall C Robinson, Ishita M Shah, Daniela Barile, David A Mills

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of food science and technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 123 citations in OpenAlex.

  1. Review
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nina KirmizFoods for Health Institute and Department of Food Science and Technology, University of California, Davis, California 95616, USA; email: damills@ucdavis.edu.
Randall C RobinsonFoods for Health Institute and Department of Food Science and Technology, University of California, Davis, California 95616, USA; email: damills@ucdavis.edu.
Ishita M ShahFoods for Health Institute and Department of Food Science and Technology, University of California, Davis, California 95616, USA; email: damills@ucdavis.edu.
Daniela BarileFoods for Health Institute and Department of Food Science and Technology, University of California, Davis, California 95616, USA; email: damills@ucdavis.edu.
David A MillsFoods for Health Institute and Department of Food Science and Technology, University of California, Davis, California 95616, USA; email: damills@ucdavis.edu.
University of California, Davis · US

Funding

Activation of probiotic bifidobacteria by milk glyansR01AT008759 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2014 to 2018
$4.2M
Necrotizing Enterocolitis: Prevention and PredictionR01HD059127 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B, MILLS, DAVID ANDREW · 2008 to 2012
$3.1M
Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk GlycansR01AT007079 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2012 to 2016
$2.2M
Oligosaccharides as antimicrobials and prebioticsR01HD065122 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2010 to 2013
$1.8M
Structures, Functions, & Genetic Diversity of Oligosaccharides in MilkR01HD061923 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B · 2009 to 2013
$1.6M
Activation of Host-Probiotic Communication by Prebiotic Milk OligosaccharidesR21AT006180 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLS, DAVID ANDREW, RAYBOULD, HELEN E · 2011 to 2012
$421k
NCCIH NIH HHS R01 AT007079NCCIH NIH HHS R01 AT008759NCCIH NIH HHS R21 AT006180NICHD NIH HHS R01 HD059127NICHD NIH HHS R01 HD061923NICHD NIH HHS R01 HD065122
6 · The paper itself

Abstract

Human milk is a unique and complex fluid that provides infant nutrition and delivers an array of bioactive molecules that serve various functions. Glycans, abundant in milk, can be found as free oligosaccharides or as glycoconjugates. Milk glycans are increasingly linked to beneficial outcomes in neonates through protection from pathogens and modulation of the immune system. Indeed, these glycans influence the development of the infant and the infant-gut microbiota. Bifidobacterium species commonly are enriched in breastfed infants and are among a limited group of bacteria that readily consume human milk oligosaccharides (HMOs) and milk glycoconjugates. Given the importance of bifidobacteria in infant health, numerous studies have examined the molecular mechanisms they employ to consume HMOs and milk glycans, thus providing insight into this unique enrichment and shedding light on a range of translational opportunities to benefit at-risk infants.

Indexed as

Gastrointestinal MicrobiomeAnimalsBifidobacteriumBreast FeedingCarbohydrate ConformationCattleDietary SupplementsGlycoconjugatesHumansInfant, NewbornMilkMilk, HumanOligosaccharidesPolysaccharidesStructure-Activity RelationshipGlycoconjugatesOligosaccharidesPolysaccharidesBifidobacteriumglycansinfant microbiotamilk oligosaccharides

Identifiers

PMID29580136
PMCPMC5999319
OpenAlexW2749004638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.