ArticleNeurobiology of aging2018
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
- dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity.Disease models & mechanisms · 2021Article
- Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity ineLife · 2021Article
- Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity.Frontiers in cell and developmental biology · 2021Article
- Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis.Neural regeneration research · 2020Review
- Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.Molecular systems biology · 2020Article
- The neuronal receptor tyrosine kinase Alk is a target for longevity.Aging cell · 2020Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.
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Registered trials
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