Polymerase bypass of N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin.

Jiayu Ye, Caitlin R Farrington, Julie T Millard

Open access · greenAbstract read

In one paragraph

Article in Mutation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 99% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jiayu YeDepartment of Chemistry, Colby College, Waterville, ME 04901, United States.

Caitlin R FarringtonDepartment of Chemistry, Colby College, Waterville, ME 04901, United States.

Julie T MillardDepartment of Chemistry, Colby College, Waterville, ME 04901, United States. Electronic address: jtmillar@colby.edu.

Colby College · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026

$60.0M

NIGMS NIH HHS P20 GM103423

6 · The paper itself

Abstract

DNA oligonucleotides containing site-specific N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin were used as templates for DNA synthesis by two bacterial DNA polymerases and human polymerase β. These polymerases were able to bypass the lesions effectively, although the efficiency was decreased, with inhibition increasing with the size of the lesion. Fidelity of incorporation was essentially unaltered, suggesting that N7-guanine monoadducts do not significantly contribute to the mutational spectra of these agents.

Indexed as

Bacterial ProteinsCisplatinDNADNA AdductsDNA Polymerase betaEpichlorohydrinEpoxy CompoundsHumansMutationBacterial ProteinsCisplatindiepoxybutaneDNADNA AdductsDNA Polymerase betaEpichlorohydrinEpoxy CompoundsPOLB protein, humanCisplatinDiepoxybutaneDNA alkylationEpichlorohydrinMutagenesisPrimer extension assay

Identifiers

PMID29579534

DOI10.1016/j.mrfmmm.2018.03.002

PMCPMC5962418

OpenAlexW2789727749

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.