Evidence map›Paper›PMID 29579400›Full record

ReviewAnnual review of chemical and biomolecular engineering2018

Biomolecular Ultrasound and Sonogenetics.

David Maresca, Anupama Lakshmanan, Mohamad Abedi, Avinoam Bar-Zion, Arash Farhadi, George J Lu, Jerzy O Szablowski, Di Wu, Sangjin Yoo, Mikhail G Shapiro

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of chemical and biomolecular engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 186 citations in OpenAlex.

  1. Review
  2. Virtual ultrasound machine operating in a GHz to MHz frequency range for particle-based biomedical simulations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Super-Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. The 2026 guided acoustic waves roadmap.Journal of physics D: Applied physics · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  17. Acoustic percolation switches enable targeted drug delivery controlled by diagnostic ultrasound.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Review
  19. Article
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David MarescaDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA; email: mikhail@caltech.edu.
Anupama LakshmananDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Mohamad AbediDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Avinoam Bar-ZionDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA; email: mikhail@caltech.edu.
Arash FarhadiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
George J LuDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA; email: mikhail@caltech.edu.
Jerzy O SzablowskiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA; email: mikhail@caltech.edu.
Di WuDivision of Engineering and Applied Sciences, California Institute of Technology, Pasadena, California 91125, USA.
Sangjin YooDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA; email: mikhail@caltech.edu.
Mikhail G ShapiroDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA; email: mikhail@caltech.edu.
California Institute of Technology · US

Funding

Biogenic Gas Nanostructures As Molecular Imaging Reporters For UltrasoundR01EB018975 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Mikhail Shapiro · 2014 to 2026
$5.9M
NIBIB NIH HHS R01 EB018975
6 · The paper itself

Abstract

Visualizing and modulating molecular and cellular processes occurring deep within living organisms is fundamental to our study of basic biology and disease. Currently, the most sophisticated tools available to dynamically monitor and control cellular events rely on light-responsive proteins, which are difficult to use outside of optically transparent model systems, cultured cells, or surgically accessed regions owing to strong scattering of light by biological tissue. In contrast, ultrasound is a widely used medical imaging and therapeutic modality that enables the observation and perturbation of internal anatomy and physiology but has historically had limited ability to monitor and control specific cellular processes. Recent advances are beginning to address this limitation through the development of biomolecular tools that allow ultrasound to connect directly to cellular functions such as gene expression. Driven by the discovery and engineering of new contrast agents, reporter genes, and bioswitches, the nascent field of biomolecular ultrasound carries a wave of exciting opportunities.

Indexed as

AnimalsBiological TransportBrainContrast MediaGenetic VectorsHumansPhotoacoustic TechniquesProteinsUltrasonicsContrast Mediagas vesicle proteinProteinsbiomoleculargas vesiclesimagingreporter genesonogeneticsultrasound

Identifiers

PMID29579400
PMCPMC6086606
OpenAlexW2793134512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.