Evidence map›Paper›PMID 29579398›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Response gene to complement 32 suppresses adipose tissue thermogenic genes through inhibiting β3-adrenergic receptor/mTORC1 signaling.

Sisi Chen, Xiaohan Mei, Amelia Yin, Hang Yin, Xiao-Bing Cui, Shi-You Chen

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Signaling pathways in obesity: mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2022
    Review
  4. Article
  5. ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.American journal of physiology. Endocrinology and metabolism · 2021
    Article
  6. Article
  7. Article
  8. RGC-32 and diseases: the first 20 years.Immunologic research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sisi ChenDepartment of Physiology and Pharmacology, University of Georgia, Athens, Georgia, USA.
Xiaohan MeiDepartment of Physiology and Pharmacology, University of Georgia, Athens, Georgia, USA.
Amelia YinDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA; and.
Hang YinDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA; and.
Xiao-Bing CuiDepartment of Physiology and Pharmacology, University of Georgia, Athens, Georgia, USA.
Shi-You ChenDepartment of Physiology and Pharmacology, University of Georgia, Athens, Georgia, USA.
Hubei University of Medicine · CNUniversity of Georgia · US

Funding

Novel mechanism of smooth muscle phenotypic modulation and vascular remodelingR01HL119053 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2023
$3.8M
Smad2 in vascular smooth muscle homeostasisR01HL135854 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2017 to 2020
$2.0M
Dedicator of Cytokinesis 2 in smooth muscle phenotype modulationR01HL123302 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2018
$1.8M
Impacts of hypoxia and hypoxia-induced factors on skeletal muscle repair and muscle stem cellsR01AR070178 · NIAMS · UNIVERSITY OF GEORGIA · PI YIN, HANG · 2016 to 2020
$1.6M
American Heart Association-American Stroke Association 17SDG32790003NHLBI NIH HHS R01 HL119053NHLBI NIH HHS R01 HL123302NHLBI NIH HHS R01 HL135854NIAMS NIH HHS R01 AR070178
6 · The paper itself

Abstract

Our previous studies have shown that response gene to complement (RGC)-32 deficiency (Rgc32

Indexed as

Adipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsCell DifferentiationComplement System ProteinsMechanistic Target of Rapamycin Complex 1Mice, KnockoutNuclear ProteinsPhosphatidylinositol 3-KinasesReceptors, Adrenergic, beta-3Signal TransductionThermogenesisComplement System ProteinsMechanistic Target of Rapamycin Complex 1Nuclear ProteinsPhosphatidylinositol 3-KinasesReceptors, Adrenergic, beta-3Rgc-32 protein, mouseenergy expenditurePI3K/AktRGC-32RNA sequencingWAT browning

Identifiers

PMID29579398
PMCPMC6103168
OpenAlexW2789784582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.