SynthesisPloS one2018
Metabolic Syndrome and cognitive decline in the elderly: A systematic review.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Metabolic syndrome and cognition: A systematic review across cognitive domains and a bibliometric analysis.Frontiers in psychology · 2022Pooled it
- Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2019Pooled it
- Sensor-measured sedentariness and physical activity are differentially related to fluid and crystallized abilities in aging.Psychology and aging · 2020Trial
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- Association of metabolic syndrome severity with cognitive decline among Chinese older adults: evidence from two prospective cohort studies.Frontiers in neuroscience · 2026Article
- Linking Metabolic Syndrome to Neurodegeneration Mechanisms and Potential Treatments.Molecular neurobiology · 2025Review
- Association of the skeletal muscle mass to visceral fat area ratio with metabolically healthy obesity and metabolically unhealthy non-obesity: a cross-sectional study based on NHANES 2011-2018.Lipids in health and disease · 2025Article
- Impact of physical activity, health literacy and cognitive health on quality of life in dyslipidemia: an observational study.Scientific reports · 2025Observational
- The Link between Metabolic Syndrome and the Brain.Digestion · 2025Review
- Examining determinants of control of metabolic syndrome among older adults with NCDs receiving service at NCD Plus clinics: multilevel analysis.BMC health services research · 2024Article
- Associations of modifiable and non-modifiable risk factors with cognitive functions - a prospective, population-based, 17 years follow-up study of 3,229 individuals.Alzheimer's research & therapy · 2024Article
- The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China.Brain sciences · 2024Article
- Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study.The journal of prevention of Alzheimer's disease · 2024Article
- Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Depression and associated factors among Brazilian adults: the 2019 national healthcare population-based study.BMC psychiatry · 2023Article
- Clustering of Cardiometabolic Risk Factors and Dementia Incidence in Older Adults: A Cross-Country Comparison in England, the United States, and China.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study.Cardiovascular diabetology · 2023Article
- Identification of a Link between Suspected Metabolic Syndrome and Cognitive Impairment within Pharmaceutical Care in Adults over 75 Years of Age.Healthcare (Basel, Switzerland) · 2023Article
- Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort.The journal of prevention of Alzheimer's disease · 2023Article
- Allostatic Load and Cognitive Function Among Urban Adults in the Healthy Aging in Neighborhoods of Diversity across the Life Span Study.Journal of Alzheimer's disease : JAD · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic Syndrome (MetS) refers to a cluster of metabolic disturbances which is associated with increased risk for vascular and degenerative conditions in general population. Although the relationship between vascular risk factors and dementia is undisputable, additional hazard for cognitive decline in older population with concurrent metabolic disorders still waits to be demonstrated. The present review aims to analyze data on MetS and risk for cognitive decline in elderly persons.
methodsDatabase searches were performed in Medline, ISI and PsycINFO for articles assessing cognitive performances of older subjects with MetS.
resultsOf a total of 505 studies, 25 were selected for the review. Risk of selection biases was identified in all the studies. Although all articles followed recognized diagnostic recommendations for MetS, minor criteria modifications were detected in most of them. Hyperglycemia was consistently associated with impaired cognitive performances in older individuals, but the role of MetS for cognitive decline and for the onset of dementia showed heterogeneous results. DISCUSSION: Current available data in the literature concerning the impact of MetS on the cognition of older population is inconclusive and based on inconsistent evidence. Differential effects of individual MetS components and factors associated with the age of the sample may have accounted for divergent findings among articles, but larger and higher quality studies in this field are still needed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.