ArticleAlzheimer disease and associated disorders
Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults: Role of Spatial Navigation Abilities.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Lost before forgetting: objective driving metrics track navigation deficits tied to preclinical Alzheimer's disease.Innovation in aging · 2026Article
- Spatial perspective taking is impaired in spinocerebellar ataxias and Friedreich ataxia.Scientific reports · 2025Article
- A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia.Scientific data · 2025Article
- Characterizing Navigational Changes in Preclinical Alzheimer's Disease: A Route Complexity Metric Derived From Naturalistic Driving Data.IEEE journal of translational engineering in health and medicine · 2025Article
- Predicting Driving Cessation Among Cognitively Normal Older Drivers: The Role of Alzheimer Disease Biomarkers and Clinical Assessments.Neurology · 2024Observational
- Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease.iScience · 2024Article
- Using Naturalistic Driving Data to Predict Mild Cognitive Impairment and Dementia: Preliminary Findings from the Longitudinal Research on Aging Drivers (LongROAD) Study.Geriatrics (Basel, Switzerland) · 2021Article
- The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults.Journal of Alzheimer's disease : JAD · 2020Article
- Developing a Spatial Navigation Screening Tool Sensitive to the Preclinical Alzheimer Disease Continuum.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019Article
- Driving Ability in Alzheimer Disease Spectrum: Neural Basis, Assessment, and Potential Use of Optic Flow Event-Related Potentials.Frontiers in neurology · 2018Review
- Driving into diagnosis: Leveraging high-resolution telematics and sensorimotor profiling to identify preclinical Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeOlder adults experience impaired driving performance, and modify their driving habits, including limiting amount and spatial extent of travel. Alzheimer disease (AD)-related pathology, as well as spatial navigation difficulties, may influence driving performance and driving behaviors in clinically normal older adults. We examined whether AD biomarkers [cerebrospinal fluid (CSF) concentrations of Aβ42, tau, and ptau181] were associated with lower self-reported spatial navigation abilities, and whether navigation abilities mediated the relationship of AD biomarkers with driving performance and extent.
methodsClinically normal older adults (n=112; aged 65+) completed an on-road driving test, the Santa Barbara Sense of Direction scale (self-report measure of spatial navigation ability), and the Driving Habits Questionnaire for an estimate of driving extent (composite of driving exposure and driving space). All participants had a lumbar puncture to obtain CSF.
resultsCSF Aβ42, but not tau or ptau181, was associated with self-reported navigation ability. Lower self-reported navigation was associated with reduced driving extent, but not driving errors. Self-reported navigation mediated the relationship between CSF Aβ42 and driving extent.
conclusionsFindings suggest that cerebral amyloid deposition is associated with lower perceived ability to navigate the environment, which may lead older adults with AD pathology to limit their driving extent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.