ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2018
Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized.
Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 34 citations in OpenAlex.
- Contact Sensitization in Adults With Atopic Dermatitis: A 21-Year Single-Center Tertiary Experience.Contact dermatitis · 2026Article
- Atopic Dermatitis beyond Eczema: A Review on its Systemic Impact through Pruritus and Associated Comorbidities.Clinical reviews in allergy & immunology · 2025Review
- Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?Clinical reviews in allergy & immunology · 2024Review
- Negative patch test findings after initiation of upadacitinib: A case report.SAGE open medical case reports · 2024Article
- Preservative Contact Hypersensitivity among Adult Atopic Dermatitis Patients.Life (Basel, Switzerland) · 2022Article
- Contact Allergy-Emerging Allergens and Public Health Impact.International journal of environmental research and public health · 2020Review
- The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center.Dermatology research and practice · 2020Article
- Sensitizing agents found in children and adolescents with recalcitrant atopic dermatitis: a cross-sectional study with a pediatric battery.Anais brasileiros de dermatologiaArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundConcomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult-to-treat. However, contact sensitization in this patient group has barely been studied.
objectiveTo study the occurrence of ACD in a population of difficult-to-treat AD children and adults.
methodsClinical and patch test information of 48 patients with difficult-to-treat AD unresponsive to conventional outpatient treatments was gathered retrospectively. We studied prevalence and relevance of common allergens, performed dynamic patch test analysis and assessed occurrence of polysensitization.
resultsIn 48 patients with difficult-to-treat AD, 75% (n = 36/48) had a concomitant contact allergy, and 39% (n = 14/36) of these patients were polysensitized. ACD and polysensitization prevalences were equal amongst children and adults. The most frequent and relevant reactions were seen against wool alcohols, surfactants cocamidopropyl betaine and dimethylaminopropylamine, bichromate and fragrance mix I. Dynamic pattern analysis showed these reactions to be mostly allergic and not irritative of nature.
conclusionDifficult-to-treat AD patients frequently suffer from concomitant (multiple) contact allergies, and this may be a reason why the AD turns into a difficult-to-treat disease. Awareness of this phenomenon is necessary, as pragmatic implementation of allergen avoidance strategies may be helpful in getting disease control in this population.
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