ArticleeLife2018
Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Hilar mossy cells control structural and functional organization in the dentate gyrus.bioRxiv : the preprint server for biology · 2026Article
- Heterosynaptic NMDA receptor plasticity in hippocampal dentate granule cells.Frontiers in synaptic neuroscience · 2026Article
- Cannabinoid agonist, WIN 55,212-2, increases in vivo paired-pulse facilitation, long-term potentiation, and Arc expression in the dentate gyrus.Brain research · 2025Article
- Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory.iScience · 2025Article
- Article
- Kv4.2 Regulates Basal Synaptic Strength by Inhibiting R-Type Calcium Channels in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses.eLife · 2024Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses.Molecular brain · 2023Article
- Real-time imaging ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
- Recurrent Excitatory Feedback From Mossy Cells Enhances Sparsity and Pattern Separation in the Dentate GyrusFrontiers in computational neuroscience · 2022Article
- Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.iScience · 2021Article
- Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.PloS one · 2021Article
- Dendritic Integration Dysfunction in Neurodevelopmental Disorders.Developmental neuroscience · 2021Review
- Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus.Nature communications · 2020Article
- Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories.Nature reviews. Neuroscience · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term potentiation (LTP) of synaptic responses is essential for hippocampal memory function. Perforant-path (PP) synapses on hippocampal granule cells (GCs) contribute to the formation of associative memories, which are considered the cellular correlates of memory engrams. However, the mechanisms of LTP at these synapses are not well understood. Due to sparse firing activity and the voltage attenuation in their dendrites, it remains unclear how associative LTP at distal synapses occurs. Here, we show that NMDA receptor-dependent LTP can be induced at PP-GC synapses without backpropagating action potentials (bAPs) in acute rat brain slices. Dendritic recordings reveal substantial attenuation of bAPs as well as local dendritic Na
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.