Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.
Mark D Ericson, Anamika Singh, Srinivasa R Tala, Erica M Haslach, Marvin L S Dirain, Jay W Schaub, Viktor Flores, Natalie Eick, Cody J Lensing, Katie T Freeman and 5 more
Article in Journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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1 · What the graph read from it
What it found
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5 · Who and what money
Authors and funding
15 authors.
Mark D Ericson
Anamika SinghDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Srinivasa R TalaDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Erica M HaslachDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Marvin L S DirainDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Jay W SchaubDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Viktor FloresDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Natalie EickDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.
Cody J Lensing
Katie T Freeman
Branden A Smeester
Danielle N Adank
Stacey L Wilber
Robert SpethCollege of Pharmacy , Nova Southeastern University , Fort Lauderdale , Florida 33328 , United States.
Carrie Haskell-LuevanoDepartments of Medicinal Chemistry and Pharmacodynamics , University of Florida , Gainesville , Florida 32610 , United States.ORCID 0000-0002-6783-5972
Funding
Endogenous G-Protein Coupled Receptor AntagonistsR01DK064250 · NIDDK · UNIVERSITY OF MINNESOTA · PI HASKELL-LUEVANO, CARRIE · 2003 to 2012
$2.6M
Melanocortin Selective LigandsR01DK091906 · NIDDK · UNIVERSITY OF MINNESOTA · PI HASKELL-LUEVANO, CARRIE · 2012 to 2015
$1.8M
Defensins as Melanocortin LigandsR01DK097838 · NIDDK · UNIVERSITY OF MINNESOTA · PI HASKELL-LUEVANO, CARRIE · 2013 to 2016
$1.7M
Novel Melanocortin Receptor Probe DiscoveryR01DK108893 · NIDDK · UNIVERSITY OF MINNESOTA · PI HASKELL-LUEVANO, CARRIE · 2016 to 2019
$1.5M
Molecular Probes of AGRP for Drug DiscoveryF32DK108402 · NIDDK · UNIVERSITY OF MINNESOTA · PI ERICSON, MARK · 2015 to 2018
β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agonists at the MCRs. Furthermore, mouse β-defensin 1 (BD1) and human BD1 are also MCR micromolar agonists. This work identifies BD1 as an endogenous MCR ligand and clarifies the controversial role of BD3 as a micromolar agonist.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors. · full record | OpenQuestion