Evidence map›Paper›PMID 29577756›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na

Jaroslava Šeflová, Petra Čechová, Tereza Štenclová, Marek Šebela, Martin Kubala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jaroslava Šeflováa Department of Biophysics, Faculty of Science , Centre of Region Haná for Biotechnological and Agricultural Research, Palacký University , Olomouc , Czech Republic.
Petra Čechováa Department of Biophysics, Faculty of Science , Centre of Region Haná for Biotechnological and Agricultural Research, Palacký University , Olomouc , Czech Republic.
Tereza Štenclováa Department of Biophysics, Faculty of Science , Centre of Region Haná for Biotechnological and Agricultural Research, Palacký University , Olomouc , Czech Republic.
Marek Šebelab Department of Protein Biochemistry and Proteomics, Faculty of Science , Centre of Region Haná for Biotechnological and Agricultural Research, Palacký University , Olomouc , Czech Republic.
Martin Kubalaa Department of Biophysics, Faculty of Science , Centre of Region Haná for Biotechnological and Agricultural Research, Palacký University , Olomouc , Czech Republic.ORCID http://orcid.org/0000-0002-3555-0016
Palacký University Olomouc · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin is the most widely used chemotherapeutic drug for the treatment of various types of cancer; however, its administration brings also numerous side effects. It was demonstrated that cisplatin can inhibit the Na

Indexed as

AnimalsAntineoplastic AgentsBinding SitesCisplatinCysteineCytoplasmMass SpectrometryMiceMolecular Dynamics SimulationMutagenesis, Site-DirectedSodium-Potassium-Exchanging ATPaseAntineoplastic AgentsCisplatinCysteineSodium-Potassium-Exchanging ATPasebinding siteC45 loopcisplatincysteine mutantsNa+/K+-ATPasesodium pump

Identifiers

PMID29577756
PMCPMC6009960
OpenAlexW2792205848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.