ArticleThe Journal of organic chemistry2018
Synthesis and Explosion Hazards of 4-Azido-l-phenylalanine.
Article in The Journal of organic chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- Exploring the causal link between serum amino acids and Parkinson's disease: a Mendelian randomization approach.Scientific reports · 2024Article
- A Methodology for the Assessment and Prioritization of Genetic Biocontainment Technologies for Engineered Microbes.Applied biosafety : journal of the American Biological Safety Association · 2024Article
- Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists.Journal of medicinal chemistry · 2023Article
- A Physical Organic Approach towards Statistical Modeling of Tetrazole and Azide Decomposition.Angewandte Chemie (International ed. in English) · 2023Article
- Hydrophilic Azide-Containing Amino Acid to Enhance the Solubility of Peptides for SPAAC Reactions.Organic letters · 2022Article
- Paramagnetic Chemical Probes for Studying Biological Macromolecules.Chemical reviews · 2022Review
- Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging.Journal of biological methods · 2022Article
- Bioorthogonal chemistry.Nature reviews. Methods primers · 2021Article
- Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents.Organic process research & development · 2020Review
- Allylic azides: synthesis, reactivity, and the Winstein rearrangement.Organic & biomolecular chemistry · 2019Review
- X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly.Journal of the American Chemical Society · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-l-phenylalanine beginning from l-phenylalanine is described. Investigations into the safety of the synthesis reveal that the Ullman-like Cu(I)-catalyzed azidation step does not represent a significant risk. The isolated 4-azido-l-phenylalanine product, however, exhibits previously undocumented explosive characteristics.
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Registered trials
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