ArticleMagnetic resonance in medicine2018
MRI detection of bacterial brain abscesses and monitoring of antibiotic treatment using bacCEST.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Chemical Exchange Saturation Transfer Imaging in Neuroinflammation: Methods, Challenges, and Recommendations.International journal of molecular sciences · 2025Review
- CEST MRI in the Management/Diagnosis of Neuroinfectious Diseases.International journal of molecular sciences · 2025Review
- Diagnostic and theranostic opportunities in Neuro-oncology.Advances in oncology · 2024Article
- Successful rescue of disseminatedJournal of biomedical research · 2024Article
- Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case-control study.Frontiers in endocrinology · 2024Article
- Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches.The Journal of infectious diseases · 2023Article
- Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances.World journal of radiology · 2022Review
- Visualizing the dynamics of tuberculosis pathology using molecular imaging.The Journal of clinical investigation · 2021Review
- Glutamate Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging in Pre-clinical and Clinical Applications for Encephalitis.Frontiers in neuroscience · 2020Article
- MRI and fluorescence studies of Saccharomyces cerevisiae loaded with a bimodal Fe(III) TJournal of inorganic biochemistry · 2019Article
- Molecular Imaging of Diabetic Foot Infections: New Tools for Old Questions.International journal of molecular sciences · 2019Review
- Differentiation of Myositis-Induced Models of Bacterial Infection and Inflammation with TTomography (Ann Arbor, Mich.) · 2019Article
- Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI.NMR in biomedicine · 2019Article
- Brain abscess in pediatric age: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles.Drug design, development and therapy · 2019Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo develop a new MRI method to detect and characterize brain abscesses using the CEST contrast inherently carried by bacterial cells, namely bacCEST.
methodsBacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats to form abscesses and tumors. The CEST signals of brain abscesses (n = 4) and tumors (n = 7) were acquired using 2 B
resultsThe bacCEST signal of S. aureus was characterized in vitro as a strong and broad signal in the range of 1 to 4 ppm, with the maximum contrast occurring at 2.6 ppm. The CEST signal in S. aureus-induced brain abscesses was significantly higher than that of contralateral parenchyma (p = .003). Moreover, thanks to their different B
conclusionBacCEST MRI provides a new imaging method to detect, discriminate, and monitor bacterial infection in deep-seated organs. Because no contrast agent is needed, such an approach has a great translational potential for detecting and monitoring bacterial infection in deep-seated organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.