ArticleItch (Philadelphia, Pa.)2017
Mrgprs activation is required for chronic itch conditions in mice.
Article in Itch (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.Biomolecules · 2026Review
- MrgprC11American journal of respiratory cell and molecular biology · 2025Article
- Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming.Dermatopathology (Basel, Switzerland) · 2025Article
- Neuroimmune interactions in atopic and allergic contact dermatitis.The Journal of allergy and clinical immunology · 2023Review
- Rg3-enriched Korean red ginseng alleviates chloroquine-induced itch and dry skin pruritus in an MrgprA3-dependent manner in mice.Integrative medicine research · 2023Article
- Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle.Science translational medicine · 2022Article
- TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model.The Journal of investigative dermatology · 2022Article
- Article
- Specific β-Defensins Stimulate Pruritus through Activation of Sensory Neurons.The Journal of investigative dermatology · 2022Article
- Peripheral Mechanisms of Itch.The Journal of investigative dermatology · 2022Review
- Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain.Heliyon · 2021Article
- Visualizing the Itch-Sensing Skin Arbors.The Journal of investigative dermatology · 2021Article
- Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- MrgprC11Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Involvement of Neuro-Immune Interactions in Pruritus With Special Focus on Receptor Expressions.Frontiers in medicine · 2021Review
- Molecular Signature of Pruriceptive MrgprA3The Journal of investigative dermatology · 2020Article
- Responses of neurons in the primary somatosensory cortex to itch- and pain-producing stimuli in rats.Journal of neurophysiology · 2020Article
- S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Peripheral and Central Mechanisms of Itch.Neuron · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionChronic itch has been drawing much attention due to its clinical significance and the complexity of its mechanisms. To facilitate the development of anti-itch strategies, it is necessary to investigate the key players in itch sensation under chronic itch conditions. Several members of the Mrgpr family were identified as itch receptors that detect cutaneous pruritogens in primary sensory neurons. However, the role of Mrgprs in chronic itch conditions has not been well described.
methodsScratching behaviors of WT and
resultsWe showed that deleting a cluster of DISCUSSION: We demonstrate that Mrgprs play important roles in mediating chronic itch and allergic itch. These findings enrich our knowledge of itch mechanism and may lead to the development of novel therapeutic approach to combat itch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.