ArticleERJ open research2018
Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors.
Article in ERJ open research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Comparative study for fatigue prevalence in subjects with diseases: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The effect of graded exercise therapy on fatigue in people with serious respiratory illness: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Multidimensional fatigue and its impact on work productivity, mood and quality of life in long-term survivors following definitive intensity-modulated radiotherapy for oropharyngeal cancer: A cross-sectional study.Journal of cancer survivorship : research and practice · 2026Article
- Resistance exercise training attenuates skeletal muscle atrophy in experimental pulmonary arterial hypertension.Pflugers Archiv : European journal of physiology · 2025Article
- Fatigue in adults with congenital heart disease aged over 40 years.International journal of cardiology. Congenital heart disease · 2025Article
- The Role of Psychological Distress on Health-Related Quality of Life, Fatigue, and Pain in Adults With Pulmonary Hypertension.Pulmonary circulation · 2025Article
- Relationships that perceived barriers to physical activity have with functional capacity and quality of life in patients with pulmonary hypertension.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Observational
- Evidence-based management of symptoms in serious respiratory illness: what is in our toolbox?European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Targeting erythrocyte-mediated hypoxia to alleviate lung injury induced by pyrrolizidine alkaloids.Archives of toxicology · 2023Article
- Development of a Physical Therapy-Based Exercise Program for Adults with Down Syndrome.International journal of environmental research and public health · 2023Review
- Multidimensional fatigue in patients with nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: incidence, severity, and risk factors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Evaluation of Effect of Curcumin on Psychological State of Patients with Pulmonary Hypertension by Magnetic Resonance Image under Deep Learning.Contrast media & molecular imaging · 2021Article
- "It is the fear of exercise that stops me" - attitudes and dimensions influencing physical activity in pulmonary hypertension patients.Pulmonary circulationArticle
- Diurnal and seasonal variation in six-minute walk distance in pulmonary hypertension: Implications for clinical monitoring.Chronic respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Pulmonary hypertension is a potentially fatal disease. Despite pharmacological advances in pulmonary hypertension, fatigue remains common in patients with pulmonary hypertension. A convenience sample of 120 participants at an international patient conference completed the Multidimensional Fatigue Inventory (MFI)-20 scale. Data on New York Heart Association Functional Class, body mass index, oxygen use and medication type/use were also collected. There was a high prevalence of "severe" to "very severe" fatigue for each dimension: General Fatigue (60%), Physical Fatigue (55.8%), Reduced Activity (41.7%), Reduced Motivation (32.5%) and Mental Fatigue (27.5%). The mean±sd overall MFI-20 score was 58±5.1. Dimensions with the highest averaged levels were General Fatigue (13.40±3.61), Physical Fatigue (13.23±3.67) and Reduced Activity (11.33±4.16). Body mass index correlated with higher fatigue scores. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination negatively predicted General Fatigue, Physical Fatigue, Reduced Motivation and Reduced Activity. Triple therapy was a significant predictor of General Fatigue, Physical Fatigue and Reduced Activity. There were no significant predictors of Mental Fatigue. Multidimensional fatigue is common and severe in patients with pulmonary hypertension. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination resulted in lower scores in most fatigue dimensions. Comprehensive assessment of fatigue should be considered in the clinical care of patients with pulmonary hypertension and clinical research to develop formal interventions that target this disabling symptom.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.