ArticleTranslational vision science & technology2018
Interindividual Variations in Foveal Anatomy and Artifacts Seen on Inner Retinal Probability Maps from Spectral Domain OCT Scans of the Macula.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Genetic insights into foveal morphology and its associations with pigmentation and age-related macular degeneration.medRxiv : the preprint server for health sciences · 2025Article
- Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma.Translational vision science & technology · 2022Article
- Macular imaging with optical coherence tomography in glaucoma.Survey of ophthalmologyReview
Corrections and comments
- Erratum issuedErratum.2018
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
purposeWe tested the hypothesis that variations in foveal morphology can account for artifacts seen on optical coherence tomography (OCT) retinal ganglion cell (RGC) layer probability maps.
methodsA total of 126 healthy subjects were tested with spectral domain (sd) OCT. Thickness and probability maps of the macular RGC plus inner plexiform layer (RGC+) were obtained with customized software. Macular b-scans were analyzed to derive three foveal anatomic parameters: width, depth, and slope. The distribution of these parameters was compared between eyes with and without circumfoveal artifacts seen in the central 4° of macular RGC+ probability maps.
resultsOf 126 healthy subjects, 12 (9.5%) had an abnormal circumfoveal region (artifact) on RGC+ probability maps. Based upon the normal distribution of the three anatomic parameters, only three of the 12 eyes (25%) fell outside the 95% confidence interval of one or more of the three foveal morphologic parameters. Multivariable logistic regression revealed that the parameter slope was significantly associated with the presence of these artifacts (odds ratio = 0.26;
conclusionsFovea morphology, as measured based upon width, depth, and slope, has a minor role in explaining artifacts seen on macular scans. Variations in the distribution of RGC+ thickness that are not reflected in our measures warrant further investigation as potential sources of artifacts. TRANSLATIONAL RELEVANCE: A small proportion of circumfoveal artifacts seen on RGC+ probability maps can be explained by variations in foveal anatomy.
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Registered trials
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