Evidence map›Paper›PMID 29576836›Full record

ArticleBiomicrofluidics2018

Hairpins in the conformations of a confined polymer.

E Werner, A Jain, A Muralidhar, K Frykholm, T St Clere Smithe, J Fritzsche, F Westerlund, K D Dorfman, B Mehlig

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

E WernerDepartment of Physics, University of Gothenburg, Origovägen 6B, 412 96 Göteborg, Sweden.
A JainDepartment of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA.ORCID 0000-0001-7580-8694
A MuralidharDepartment of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA.
K FrykholmDepartment of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Göteborg, Sweden.
T St Clere SmitheDepartment of Physics, University of Gothenburg, Origovägen 6B, 412 96 Göteborg, Sweden.
J FritzscheDepartment of Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden.
F WesterlundDepartment of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Göteborg, Sweden.
K D DorfmanDepartment of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA.ORCID 0000-0003-0065-5157
B MehligDepartment of Physics, University of Gothenburg, Origovägen 6B, 412 96 Göteborg, Sweden.ORCID 0000-0002-3672-6538
Chalmers University of Technology · SEUniversity of Gothenburg · SEUniversity of Minnesota · US

Funding

Dynamics of DNA Barcoding in NanochannelsR01HG006851 · NHGRI · UNIVERSITY OF MINNESOTA · PI DORFMAN, KEVIN D · 2013 to 2018
$2.1M
NHGRI NIH HHS R01 HG006851
6 · The paper itself

Abstract

If a semiflexible polymer confined to a narrow channel bends around by 180°, the polymer is said to exhibit a hairpin. The equilibrium extension statistics of the confined polymer are well understood when hairpins are vanishingly rare or when they are plentiful. Here, we analyze the extension statistics in the intermediate situation via experiments with DNA coated by the protein RecA, which enhances the stiffness of the DNA molecule by approximately one order of magnitude. We find that the extension distribution is highly non-Gaussian, in good agreement with Monte-Carlo simulations of confined discrete wormlike chains. We develop a simple model that qualitatively explains the form of the extension distribution. The model shows that the tail of the distribution at short extensions is determined by conformations with one hairpin.

Identifiers

PMID29576836
PMCPMC5844772
OpenAlexW2785578643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.