ArticleDental research journal
Effectiveness of MI Paste Plus and Remin Pro on remineralization and color improvement of postorthodontic white spot lesions.
Article in Dental research journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the Application of Infiltrative Resins: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effectiveness of remineralizing agents in the prevention and reversal of orthodontically induced white spot lesions: a systematic review and network meta-analysis.Clinical oral investigations · 2020Pooled it
- Clinical effectiveness of theobromine, Remin Pro, and their combination in managing dentin hypersensitivity: a randomized clinical trial.BMC oral health · 2026Trial
- Effect of nanohydroxyapatite paste after different pretreatment techniques on remineralization and color change of white spot lesions in children: a randomized control study.BMC oral health · 2026Trial
- Effect of remineralization after in office followed by home treatment of white spot lesions in children randomized controlled trial.Scientific reports · 2025Trial
- Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial.Clinical oral investigations · 2023Trial
- Remineralising efficacy of bioactive glass and casein phosphopeptide amorphous calcium phosphate in white spot lesions or early enamel caries: A systematic review of randomised controlled trials.The Japanese dental science review · 2026Review
- Article
- The comparative evaluation for the efficacy of different remineralization agents on initial caries lesion.BMC oral health · 2026Article
- The Impact of Antimicrobial Photodynamic Therapy (aPDT) with Various Photosensitizers on the Bond Strength of Orthodontic Brackets.Journal of lasers in medical sciences · 2026Article
- Fluoride in Dental Caries Prevention and Treatment: Mechanisms, Clinical Evidence, and Public Health Perspectives.Healthcare (Basel, Switzerland) · 2025Review
- Effect of biomimetic tooth mousse and toothpaste on the incidence of white spot lesions during fixed appliance orthodontic treatment: A randomized clinical trial.Journal of Taibah University Medical Sciences · 2025Article
- White Spot Lesion Treatment Options: A Systematic Review of Different Techniques for Masking These Lesions.Gels (Basel, Switzerland) · 2025Review
- Internal bleaching with calcium oxalate and laser irradiation for managing discolorations induced by mineral trioxide aggregate.BMC oral health · 2025Article
- Effect of the use of remineralization agents before resin infiltration on the treatment of initial enamel lesions: an in-vitro study.BMC oral health · 2024Article
- Effects of Two Remineralizing Agents in Combination with Er:YAG and COFrontiers in dentistry · 2024Article
- Photoinactivation Effects of Curcumin, Nano-curcumin, and Erythrosine on Planktonic and Biofilm Cultures ofJournal of lasers in medical sciences · 2024Article
- Analysis of Dental Enamel Remineralization: A Systematic Review of Technique Comparisons.Bioengineering (Basel, Switzerland) · 2023Review
- Comparative Efficacy of Novel Biomimetic Remineralising Technologies.Biomimetics (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis clinical trial investigated the effectiveness of two remineralizing creams on regression of white spot lesions (WSLs) after orthodontic therapy. MATERIALS AND
methodsThe study included patients with WSLs on their upper anterior teeth who recently completed orthodontic treatment at the Department of Orthodontics of Mashhad Dental School and two private offices. The participants were randomly assigned into three groups by treatment: (1) a 12-week regimen of a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); (2) a 12-week regimen of a cream containing hydroxyapatite and fluoride (Remin Pro); and (3) usual home care (control). Thirty-nine patients participated and three withdrew. The main outcomes including area, mineral content, and color of WSLs were measured at enrolment and 4, 8, and 12 weeks later, respectively. Blinding was applied for outcome assessment only. The data were analyzed by analysis of variance and repeated measures analysis at the statistical significance of
resultsOver a 3-month period, the application of both MI Paste Plus and Remin Pro caused significantly greater reduction in area and significantly higher increase in mineral content of WSLs compared to the control group (
conclusionThe application of either MI Paste Plus or Remin Pro was effective in reducing the area, increasing the mineral content and improving the appearance of demineralized enamel, indicating that these products could be recommended for managing postorthodontic WSLs.
Indexed as
Identifiers
29576772PMC5858078W2789738238What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.