ArticlePharmacognosy magazine
Combined Antihypertensive Effect of Paeoniflorin Enriched Extract and Metoprolol in Spontaneously Hypertensive Rats.
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
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- Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology.Frontiers in pharmacology · 2025Review
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- Marine sourced tripeptide SRP and its sustained-release formulation SRP-PLGA-MS exhibiting antihypertensive effect in spontaneously hypertensive rats and HUVECs.Frontiers in nutrition · 2024Article
- Batteryless implantable device with built-in mechanical clock for automated and precisely timed drug administration.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Protective effects of paeoniflorin on cardiovascular diseases: A pharmacological and mechanistic overview.Frontiers in pharmacology · 2023Review
- Integration of Chinese Herbal Medicine into Routine Care Was Related to Lower Risk of Chronic Kidney Disease in Patients with Rheumatoid Arthritis: A Population-Based Nested Case-Control Study in Taiwan.Journal of multidisciplinary healthcare · 2023Article
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- Polysaccharide, the Active Component ofFrontiers in pharmacology · 2022Article
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- Anti-inflammatory effect of Ganluyin, a Chinese classic prescription, in chronic pharyngitis rat model.BMC complementary medicine and therapies · 2020Article
- Analysis of the Overlapped Electrochemical Signals of Hydrochlorothiazide and Pyridoxine on the Ethylenediamine-Modified Glassy Carbon Electrode by Use of Chemometrics Methods.Molecules (Basel, Switzerland) · 2019Article
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- Alcohol Induces More Severe Fatty Liver Disease by Influencing Cholesterol Metabolism.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Hypertensive Rats Treated Chronically With NFrontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is a great global health challenge and it mostly requires drug combination therapy with the various advantages. Metoprolol (MP) and paeoniflorin are both commonly used for the treatment of hypertension. However, whether they exert synergistic effects on antihypertension or not remains unclear, especially on vascular endothelial function.
objectiveThe purpose of the study is to investigate the advantages of the combined antihypertensive effects of paeoniflorin enriched extract from Radix MATERIALS AND
methodsSHR divided into six groups (
resultsThe results showed that MP + RE significantly reduced BP, increased microcirculation, improved vascular function and pathological changes, and upregulated eNOS expression. MP was also found to increase the blood concentration of paeoniflorin in SD.
conclusionThe combination of RE and MP could be used for the treatment of hypertension and could improve microcirculation, upregulate eNOS expression, and mitigate endothelial dysfunction in SHR. SUMMARY: Paeoniflorin enriched extract from Radix
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