Evidence map›Paper›PMID 29576623›Full record

ArticleBritish journal of cancer2018

Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry.

Isabel Quiros-Gonzalez, Michal R Tomaszewski, Sarah J Aitken, Laura Ansel-Bollepalli, Leigh-Ann McDuffus, Michael Gill, Lina Hacker, Joanna Brunker, Sarah E Bohndiek

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Early Radiation Therapy Response Assessment Using Multi-Scale Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Unlocking the Therapeutic Potential of Integrin-Linked Kinase Inhibitors in Bioengineered 3D Breast Tumor Stroma Models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Unravelling theTheranostics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Isabel Quiros-GonzalezDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Michal R TomaszewskiDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Sarah J AitkenCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Laura Ansel-BollepalliDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Leigh-Ann McDuffusCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Michael GillCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
Lina HackerDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Joanna BrunkerDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Sarah E BohndiekDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK. seb53@cam.ac.uk.
University of Cambridge · GBCancer Research UK · GBCambridge University Hospitals NHS Foundation Trust · GB

Funding

Cancer Research UK 16267Cancer Research UK 16465Cancer Research UK C14303/A17197Cancer Research UK C197/A16465Cancer Research UK C47594/A16267
6 · The paper itself

Abstract

backgroundOptoacoustic tomography (OT) of breast tumour oxygenation is a promising new technique, currently in clinical trials, which may help to determine disease stage and therapeutic response. However, the ability of OT to distinguish breast tumours displaying different vascular characteristics has yet to be established. The aim of the study is to prove OT as a sensitive technique for differentiating breast tumour models with manifestly different vasculatures.

methodsMultispectral OT (MSOT) was performed in oestrogen-dependent (MCF-7) and oestrogen-independent (MDA-MB-231) orthotopic breast cancer xenografts. Total haemoglobin (THb) and oxygen saturation (SO

resultsMCF-7 tumours show SO

conclusionsOT is sensitive to differences in the vascular phenotypes of our breast cancer models.

Indexed as

AnimalsBiological MimicryBreast NeoplasmsCell Line, TumorDrug MonitoringFemaleHumansMammary Neoplasms, ExperimentalMCF-7 CellsMiceMice, Inbred BALB CMice, NudeNeoplasm StagingNeovascularization, PathologicOxygen ConsumptionPhotoacoustic Techniques

Identifiers

PMID29576623
PMCPMC5931091
OpenAlexW2792755823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.