ArticleMolecular cell2018
Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus.
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Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Igh nuclear speckle association promotes V(D)J recombination.Nature communications · 2026Article
- Immunoglobulin gene polymorphisms shape the naïve B-cell receptor repertoire; relevance to celiac disease.Genes and immunity · 2026Article
- Chromatin folding principles underlying the generation of antibody diversity.Molecular cell · 2026Article
- Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus.Nature communications · 2025Article
- Addressing Technical Pitfalls in Pursuit of Molecular Factors That Mediate Immunoglobulin Gene Regulation.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Lineage- and stage-specific activity of antigen receptor gene enhancers during lymphocyte development.Frontiers in epigenetics and epigenomics · 2024Review
- Enhancers within the Ig V Gene Region Orchestrate Chromatin Topology and Regulate V Gene Rearrangement Frequency to Shape the B Cell Receptor Repertoire Specificities.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes.Cell reports · 2023Article
- Multiple lineage-specific epigenetic landscapes at the antigen receptor loci.Aging research (Hong Kong, China) · 2023Article
- An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation.Nature communications · 2023Article
- Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens.Nature immunology · 2023Article
- Locus architecture and RAG scanning determine antibody diversity.Trends in immunology · 2023Review
- The role of chromatin loop extrusion in antibody diversification.Nature reviews. Immunology · 2022Review
- A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters.Nucleic acids research · 2022Article
- Contribution of Immunoglobulin Enhancers to B Cell Nuclear Organization.Frontiers in immunology · 2022Review
- Review
- Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire.Frontiers in immunology · 2021Review
- Spatial Organization of Chromatin: Transcriptional Control of Adaptive Immune Cell Development.Frontiers in immunology · 2021Review
- Altered 3D chromatin structure permits inversional recombination at theScience advances · 2020Article
- Genome Topology Control of Antigen Receptor Gene Assembly.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Xiang QiuLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Gita KumariLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Tatiana GerasimovaLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Hansen DuLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Lawal LabaranLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Amit SinghLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.
Supriyo DeLaboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
William H WoodLaboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
Kevin G BeckerLaboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
Weiqiang ZhouDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Ranjan SenLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA. Electronic address: senranja@grc.nia.nih.gov.
National Institute on Aging · USJohns Hopkins University · US
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MAnalysis of complex biological systems by microarray based gene expressionZICAG000616 · NIA · NATIONAL INSTITUTE ON AGING · PI DE, SUPRIYO · 2009 to 2025
$15.5MChromosome movements that regulate tissue-specific gene expressionZIAAG000373 · NIA · NATIONAL INSTITUTE ON AGING · PI SEN, RANJAN · 2009 to 2025
$9.7MGene Regulation in LymphocytesZIAAG000383 · NIA · NATIONAL INSTITUTE ON AGING · PI SEN, RANJAN · 2009 to 2025
$8.2MActivation and inactivation of VH gene recombinationZIAAG000372 · NIA · NATIONAL INSTITUTE ON AGING · PI SEN, RANJAN · 2009 to 2021
$4.9MNCI NIH HHS P30 CA006973
Abstract
Immunoglobulin heavy-chain (IgH) genes are assembled by DNA rearrangements that juxtapose a variable (V
Indexed as
Chromatin Assembly and DisassemblyEnhancer Elements, GeneticGenes, Immunoglobulin Heavy ChainGenetic LociRecombination, GeneticAnimalsBinding SitesCCCTC-Binding FactorCell LineDNA-Binding ProteinsDNA, IntergenicImmunoglobulin Variable RegionMice, 129 StrainMice, KnockoutNucleic Acid ConformationPrecursor Cells, B-LymphoidCCCTC-Binding FactorCtcf protein, mouseDNA-Binding ProteinsDNA, IntergenicImmunoglobulin Variable RegionRag2 protein, mouseYy1 protein, mouseYY1 Transcription FactorCTCF binding elementenhancerIGCR1IgHrecombination center
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.