Trial reportJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2018
Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging.
Trial report in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of Augmentation Index With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.American journal of hypertension · 2025Pooled it
- White Matter Hyperintensities and Functional Outcomes in Patients With Cerebral Hemorrhage: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of stroke · 2020Pooled it
- Brain Atrophy and White Matter Changes Grading Agreement on NCCT and MRI in Ischemic Stroke.Clinical neuroradiology · 2026Trial
- White matter lesions modifying endovascular therapy outcomes in large ischemic core stroke: A secondary analysis of the ANGEL-ASPECT trial.Chinese medical journal · 2026Trial
- Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.JAMA network open · 2024Trial
- Impact of brain frailty on language recovery in patients with acute post-stroke aphasia: a post-hoc analysis of the LEXI randomized controlled trial.Neurological research and practice · 2026Article
- White Matter Hyperintensities on Admission CT are Associated with Worse Outcomes But Not Cerebral Edema or Hemorrhagic Transformation After Large Vessel Occlusion Stroke.Neurocritical care · 2026Article
- Machine learning-based prediction of 3-6-month post-stroke cognitive impairment using acute-phase clinical data: a two-center retrospective prognostic modeling study.BMC medical informatics and decision making · 2026Article
- The potential of low-field MRI for global dementia care.Nature reviews. Neurology · 2026Review
- White Matter Hyperintensities on Admission CT Are Associated with Worse Outcomes but not Cerebral Edema or Hemorrhagic Transformation after Large Vessel Occlusion Stroke.Research square · 2026Article
- Early Clinical, Laboratory, and Imaging Correlates of Neurological Dysfunction in Adults Presenting to the Emergency Department with Sepsis: A Single-Center Retrospective Study.Juntendo medical journal · 2026Article
- Advantage of grading classification using volumetric artificial intelligence for periventricular hyperintensity and deep subcortical white matter hyperintensity.Scientific reports · 2025Article
- Incidentally discovered Covert Cerebrovascular Disease by CT versus MRI: Agreement and Prognostic Value for Stroke and Dementia in a Large Real-World Cohort.medRxiv : the preprint server for health sciences · 2025Article
- Hypertension, intracranial arteriosclerosis, and structural brain changes in patients with TIA or ischemic stroke.European stroke journal · 2025Article
- Leukoaraiosis does not impact motor outcomes in Parkinson's patients post deep brain stimulation.Clinical parkinsonism & related disorders · 2025Article
- Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke.International journal of molecular sciences · 2024Observational
- Reliability of the global cortical atrophy visual rating scale applied to computed tomography versus magnetic resonance imaging scans in acute stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Differential blood-based biomarkers of subcortical and deep brain small vessel disease.Therapeutic advances in neurological disorders · 2024Article
- Comparing the Efficacy of Two Cognitive Screening Tools in Identifying Gray and White Matter Brain Damage among Older Adults.Journal of aging research · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
goalMagnetic resonance imaging (MRI) is the preferred modality for research on structural age-related brain changes. However, computed tomography (CT) is widely available and has practical and cost advantages over MRI for large-scale brain imaging research studies in acutely unwell patients. However, the relationships between MRI and CT measures of white matter hyperintensities (WMH) and atrophy are unclear. We examined the relationships between visual ratings of WMH, atrophy, and old infarcts in patients who had both CT and MRI scans. MATERIALS AND
methodsPatients who had both CT and MRI scans in the International Stroke Trial-3 were studied. In both modalities, 2 raters independently completed standardized visual rating scales for WMH, and for central and superficial atrophy using a 5-point scale. In addition, 1 rater recorded old infarcts according to size and location.
findingsSeventy patients with a mean age of 69 years were studied. There were moderate to substantial intrarater CT-MRI agreements for periventricular components of WMH scales (weighted Κappa = .55-.75). Agreements for basal ganglia ratings were lower (weighted Κappa = .18-.44), partly because of the misclassification of prominent perivascular spaces. Atrophy scales showed moderate to substantial CT-MRI agreements (weighted Κappa = .44-.70). MRI was more sensitive in the detection of smaller infarcts and cavitated lesions.
conclusionsStandardized visual rating scales of white matter lesions and atrophy mostly show substantial agreement between CT and MRI. Clinical CT scans have a strong potential for wider exploitation in research studies, particularly in acutely unwell populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.