ArticleBritish journal of anaesthesia2018
Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats.
Article in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pharmacological interventions for preventing opioid-induced hyperalgesia in adults after opioid-based anesthesia: a systematic review and network meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial.Drug design, development and therapy · 2026Trial
- Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients.Pain research & management · 2021Trial
- Modulating morphine-induced conditioned place preference: The role of diclofenac sodium.Toxicology reports · 2025Article
- Gene expression in the dorsal root ganglion and the cerebrospinal fluid metabolome in polyneuropathy and opioid tolerance in rats.IBRO neuroscience reports · 2024Article
- Immune-mediated impairment of tonic immobility defensive behavior in an experimental model of colonic inflammation.Pflugers Archiv : European journal of physiology · 2024Article
- The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial.European journal of dentistry · 2023Article
- An Exploratory Pilot Study of Changes in Global DNA Methylation in Patients Undergoing Major Breast Surgery Under Opioid-Based General Anesthesia.Frontiers in pharmacology · 2021Article
- Divergent profiles of fentanyl withdrawal and associated pain in mice and rats.Pharmacology, biochemistry, and behavior · 2021Article
- Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine "Medicines (Basel, Switzerland) · 2020Article
- Effect of Acute Administration of Caffeine on Neuropathic Pain and the Role of Nitric Oxide Pathway in an Animal Model of Chronic Constriction Injury.Basic and clinical neuroscienceArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAccumulated evidence suggests that spinal cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) may be implicated in the development of opioid-induced hyperalgesia.
methodsRats received subcutaneous fentanyl injections at different doses (20-80 μg kg
resultsAcute repeated injections of fentanyl dose-dependently induced mechanical hyperalgesia, which reached a peak at the 1
conclusionsAcute repeated fentanyl administration dose-dependently produced mechanical hyperalgesia and augmented surgery induced postoperative hyperalgesia. This behavioural change was paralleled with an increase in spinal COX-2 mRNA and PGE2 after fentanyl administration. Inhibition of COX-2 or blockade of EP-1R can partly or totally prevent hyperalgesia.
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