ArticleJournal of the International Neuropsychological Society : JINS2018
Anomalous Brain Development Is Evident in Preschoolers With Attention-Deficit/Hyperactivity Disorder.
Article in Journal of the International Neuropsychological Society : JINS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Developmental deviations of association-network structural connectivity in youths with ADHD predict symptom and treatment outcomes.Nature biomedical engineering · 2026Article
- The utility of multiple assessments in infancy and toddlerhood to predict middle childhood ADHD symptoms: Temperamental, behavioral, and genetic contributions.Infant behavior & development · 2025Article
- Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD.Frontiers in human neuroscience · 2025Article
- Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain.Child and adolescent psychiatry and mental health · 2023Article
- Do Children with Attention Deficit and Hyperactivity Disorder Present with Different Spatio-Temporal Gait Parameters? An Evaluation of the Relationship Between Gait and Gross Motor Skills.Alpha psychiatry · 2023Article
- Structural and diffusion-weighted brain imaging predictors of attention-deficit/hyperactivity disorder and its symptomology in very young (4- to 7-year-old) children.The European journal of neuroscience · 2022Article
- Childhood symptoms of attention-deficit/hyperactivity disorder and borderline personality disorder.Acta psychiatrica Scandinavica · 2022Article
- Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain.Translational psychiatry · 2022Article
- Adverse childhood experiences predict neurite density differences in young children with and without attention deficit hyperactivity disorder.Developmental psychobiology · 2022Article
- Atypical sulcal pattern in boys with attention-deficit/hyperactivity disorder.Human brain mapping · 2021Article
- Co-Occurrence of Neurodevelopmental Disorders in Pediatric Sickle Cell Disease.Journal of developmental and behavioral pediatrics : JDBP · 2021Article
- Gray matter networks associated with attention and working memory deficit in ADHD across adolescence and adulthood.Translational psychiatry · 2021Article
- Synaptic development of layer V pyramidal neurons in the prenatal human prefrontal neocortex: a Neurolucida-aided Golgi study.Neural regeneration research · 2020Article
- Gait control in children with attention-deficit/hyperactivity disorder.Human movement science · 2020Article
- Design Fluency in Children with ADHD and Comorbid Disorders.Brain sciences · 2020Article
- Diagnosis and Treatment Options for Preschoolers with Attention-Deficit/Hyperactivity Disorder.Journal of child and adolescent psychopharmacology · 2020Review
- Abnormal Structure and Function of Parietal Lobe in Individuals With Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review Study.Basic and clinical neuroscienceReview
- Does ADHD worsen inhibitory control in preschool children born very premature and/or with very low birth weight?Trends in psychiatry and psychotherapyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesAttention-deficit/hyperactivity disorder (ADHD) is a common neurological disorder with symptom onset early in childhood. Growing evidence suggests anomalous brain development across multiple brain regions is evident in school-aged children; however, few studies have examined whether such differences are notable in the preschool years when symptom onset typically occurs.
methodsHigh resolution anatomical (MPRAGE) images and cognitive and behavioral measures were analyzed in a total of 90 medication-naïve preschoolers, ages 4-5 years (52 with ADHD, 38 controls; 64.4% boys).
resultsResults revealed reductions in bilateral frontal, parietal, and temporal lobe gray matter volumes in children with ADHD relative to typically developing children, with largest effect sizes noted for right frontal and left temporal lobe volumes. Examining frontal lobe sub-regions, the largest between group effect sizes were evident for left orbitofrontal cortex, left primary motor cortex (M1), and left supplementary motor complex (SMC). ADHD-related reductions in specific sub-regions (left prefrontal, left premotor, left frontal eye field, left M1, and right SMC) were significantly correlated with symptom severity, such that higher ratings of hyperactive/impulsive symptoms were associated with reduced cortical volumes.
conclusionsThese findings represent the first comprehensive examination of cortical volume in preschool children with ADHD, providing evidence that anomalous brain structure in ADHD is evident very early in development. Furthermore, findings set the stage for developing our understanding of the way in which developmental trajectories of anomalous brain development are associated with the unfolding of symptoms in childhood ADHD. (JINS, 2018, 24, 531-539).
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