Evidence map›Paper›PMID 29575995›Full record

ArticleJournal of child neurology2018

Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors.

Matthew Nordstrom, Erin Felton, Katherine Sear, Benita Tamrazi, Joseph Torkildson, Karen Gauvain, Daphne A Haas-Kogan, Josephine Chen, Benedict Del Buono, Anuradha Banerjee and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  10. Article
  11. Review
  12. Stroke-like migraine attacks after radiation therapy (SMART) syndrome-a case series and review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Review
  13. Article
  14. Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Matthew Nordstrom1 Department of Pediatrics, University of California, San Francisco, CA, USA.
Erin Felton2 Department of Neurology, University of California, San Francisco, CA, USA.
Katherine Sear2 Department of Neurology, University of California, San Francisco, CA, USA.
Benita Tamrazi3 Department of Radiology, Children's Hospital of Los Angeles, CA, USA.
Joseph Torkildson4 Department of Pediatrics, UCSF Benioff Children's Hospital Oakland, CA, USA.
Karen Gauvain5 Department of Pediatrics, Washington University, St. Louis, Missouri, CA, USA.
Daphne A Haas-Kogan6 Department of Radiation Oncology, Brigham and Woman's Hospital, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, CA, USA.
Josephine Chen7 Department of Radiation Oncology, University of California, San Francisco, CA, USA.
Benedict Del Buono2 Department of Neurology, University of California, San Francisco, CA, USA.
Anuradha Banerjee1 Department of Pediatrics, University of California, San Francisco, CA, USA.
David Samuel9 Department of Pediatrics, Valley Children's Hospital, Madera, CA, USA.
David Saloner10 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Bing Tian10 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Erika Roddy11 School of Medicine, University of California, San Francisco, CA, USA.
Christopher Hess2 Department of Neurology, University of California, San Francisco, CA, USA.
Heather Fullerton1 Department of Pediatrics, University of California, San Francisco, CA, USA.
Sabine Mueller1 Department of Pediatrics, University of California, San Francisco, CA, USA.
University of California, San Francisco · USNeurological Surgery · USBoston Children's Hospital · USChildren's Hospital Central California · USChildren's Hospital of Los Angeles · USUCSF Benioff Children's Hospital · USWashington University in St. Louis · US

Funding

Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
NCATS NIH HHS KL2 TR000143
6 · The paper itself

Abstract

Among childhood cancer survivors, increased stroke risk after cranial radiation therapy may be caused by radiation-induced arteriopathy, but limited data exist to support this hypothesis. Herein, we assess the timing and presence of cerebral arteriopathy identified by magnetic resonance angiography (MRA) after cranial radiation therapy in childhood brain tumor survivors. In a cohort of 115 pediatric brain tumor survivors, we performed chart abstraction and prospective annual follow-up to assess the presence of large vessel cerebral arteriopathy by MRA. We identified 10 patients with cerebral arteriopathy. The cumulative incidence of arteriopathy 5 years post-cranial radiation therapy was 5.4% (CI 0.6%-10%) and 10 years was 16% (CI 4.6%-26%). One patient had an arterial ischemic stroke 2.4 years post-cranial radiation therapy in the distribution of a radiation-induced stenotic artery. We conclude that large vessel arteriopathies can occur within a few years of cranial radiation therapy and can become apparent on MRA in under a year.

Indexed as

Brain NeoplasmsCancer SurvivorsCerebral AngiographyCerebral Arterial DiseasesChildChild, PreschoolCranial IrradiationFemaleFollow-Up StudiesHumansIncidenceMagnetic Resonance AngiographyMaleProspective StudiesRadiation InjuriesTime Factorsbrain tumorMRIneurooncologypediatricstroke

Identifiers

PMID29575995
PMCPMC5873308
OpenAlexW2790295793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.