Evidence map›Paper›PMID 29575972›Full record

ArticlePulmonary circulation

Pulmonary arterial hypertension and atrial arrhythmias: incidence, risk factors, and clinical impact.

Valentina Mercurio, Grace Peloquin, Khalil I Bourji, Nermin Diab, Takahiro Sato, Blessing Enobun, Traci Housten-Harris, Rachel Damico, Todd M Kolb, Stephen C Mathai and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04554160 (ArrhythmiaS in Pulmonary arterIal hypeRtEnsion and Right Heart Failure Assessed by Continuous Long-term Cardiac Monitoring), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04554160 unknown statusnot on this map

ArrhythmiaS in Pulmonary arterIal hypeRtEnsion and Right Heart Failure Assessed by Continuous Long-term Cardiac Monitoring

TypeobservationalSponsorRigshospitalet, DenmarkRan2018 to 2024Enrolled40ConditionsPulmonary Hypertension, Arrhythmias, Cardiac, Heart Rate Variability, Risk AssessmentArmsLoop recorder implantation, A smartwatch
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  5. Observational
  6. Article
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  14. Sudden cardiac death in pulmonary arterial hypertension.International journal of cardiology. Congenital heart disease · 2024
    Review
  15. Cardiac Arrhythmias in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Mechanistic Insights, Pathophysiology, and Outcomes.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Valentina Mercurio1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Grace Peloquin1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Khalil I Bourji1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Nermin Diab3 25802 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Takahiro Sato1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Blessing Enobun1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Traci Housten-Harris1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Rachel Damico1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Todd M Kolb1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Stephen C Mathai1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Ryan J Tedford4 Division of Cardiology, 1466 Department of Medicine, Johns Hopkins University , Baltimore, MD, USA.
Carlo G Tocchetti2 Department of Translational Medical Sciences, 1466 Federico II University, Naples, Italy.
Paul M Hassoun1 Division of Pulmonary and Critical Care Medicine, 1466 Department of Medicine, Johns Hopkins University, Baltimore , MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USFederico II University Hospital · IT

Funding

Mechanisms of Right Ventricular Dysfunction in Scleroderma-associated PAHR01HL114910 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M. · 2012 to 2023
$6.2M
Hopkins Clinical Center for Pulmonary Vascular Disease Phenomics ProgramU01HL125175 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M., MATHAI, STEPHEN C · 2015 to 2019
$1.1M
NHLBI NIH HHS R01 HL114910NHLBI NIH HHS U01 HL125175
6 · The paper itself

Abstract

Atrial arrhythmia (AA) occurrence in pulmonary arterial hypertension (PAH) may determine clinical deterioration and affect prognosis. In this study we assessed AA incidence in idiopathic (IPAH) and systemic sclerosis related PAH (SSc-PAH) and evaluated risk factors, management, and impact on mortality. We collected baseline data from consecutive IPAH or SSc-PAH patients prospectively enrolled in the Johns Hopkins Pulmonary Hypertension Registry between January 2000 and July 2016. During follow-up AA onset, treatment, and outcome were recorded. Among 317 patients (201 SSc-PAH, 116 IPAH), 42 developed AA (19 atrial fibrillation, 10 flutter-fibrillation, 9 atrial flutter, and 4 atrial ectopic tachycardia) with a 13.2% cumulative incidence. Most events were associated with hospitalization (90.5%). Electrical or pharmacological cardioversion was attempted in most cases. Patients with AA had higher right atrial pressure, pulmonary wedge pressure ( P < 0.005), NT-proBNP ( P < 0.05), and thyroid disease prevalence ( P < 0.005). Higher mortality was observed in patients with AA, though not statistically significant (LogRank P = 0.323). Similar long-term mortality between IPAH with AA and SSc-PAH without AA was observed (LogRank P = 0.098). SSc-PAH with AA had the worst prognosis. In PAH patients AA occurrence is a matter of significant concern. Therapeutic strategies aimed at restoring sinus rhythm may represent an important goal.

Indexed as

atrial arrhythmiaspulmonary arterial hypertensionsystemic sclerosis

Identifiers

PMID29575972
PMCPMC5912291
OpenAlexW2790114455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.