ArticleJournal of biomedical optics2018
Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Optical phantoms for the characterization and validation of imaging and spectroscopy: a review.Biophotonics discovery · 2026Review
- Development and characterization of a combined fluorescence and spatial frequency domain imaging system for real-time dosimetry of photodynamic therapy.Journal of biomedical optics · 2025Article
- Development of a multiparameter phantom system for multispectral imaging.Biomedical optics express · 2025Article
- Solid breast tumors phantom emulating oxy and deoxyhemoglobin concentrations for near infrared imaging.PloS one · 2025Article
- Dual-mode OCT/fluorescence system for monitoring the morphology and metabolism of laser-printed 3D full-thickness skin equivalents.Biomedical optics express · 2024Article
- Non-invasive optical and laboratory hematologic biomarkers correlate in patients with sickle cell disease.Biomedical optics express · 2024Article
- Quantifying tissue properties and absolute hemodynamics using coherent spatial imaging.Journal of biomedical optics · 2023Article
- Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury.Neurophotonics · 2023Review
- Speed-resolved perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning.Journal of biomedical optics · 2023Article
- Development of a platform for broadband, spectra-fitted, tissue optical phantoms.Journal of biomedical optics · 2023Article
- Characterizing tourniquet induced hemodynamics during total knee arthroplasty using diffuse optical spectroscopy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Observational
- Smartphone-based single snapshot spatial frequency domain imaging.Biomedical optics express · 2022Article
- Camera-Derived Photoplethysmography (rPPG) and Speckle Plethysmography (rSPG): Comparing Reflective and Transmissive Mode at Various Integration Times Using LEDs and Lasers.Sensors (Basel, Switzerland) · 2022Article
- Spectral characterization of liquid hemoglobin phantoms with varying oxygenation states.Journal of biomedical optics · 2021Article
- Detection of cutaneous oxygen saturation using a novel snapshot hyperspectral camera: a feasibility study.Quantitative imaging in medicine and surgery · 2021Article
- Multi-modal diffuse optical spectroscopy for high-speed monitoring and wide-area mapping of tissue optical properties and hemodynamics.Journal of biomedical optics · 2021Article
- Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection.Journal of biomedical optics · 2021Article
- High-speed quantitative optical imaging of absolute metabolism in the rat cortex.Neurophotonics · 2021Article
- Multimodal Optical Imaging to Investigate Spatiotemporal Changes in Cerebrovascular Function in AUDA Treatment of Acute Ischemic Stroke.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive disease. We present and validate a noncontact method for quantitatively mapping tMRO2 over a wide, scalable field of view at 16 frames / s. We achieve this by developing a dual-wavelength, near-infrared coherent spatial frequency-domain imaging (cSFDI) system to calculate tissue optical properties (i.e., absorption, μa, and reduced scattering, μs', parameters) as well as the speckle flow index (SFI) at every pixel. Images of tissue oxy- and deoxyhemoglobin concentration ( [ HbO2 ] and [HHb]) are calculated from optical properties and combined with SFI to calculate tMRO2. We validate the system using a series of yeast-hemoglobin tissue-simulating phantoms and conduct in vivo tests in humans using arterial occlusions that demonstrate sensitivity to tissue metabolic oxygen debt and its repayment. Finally, we image the impact of cyanide exposure and toxicity reversal in an in vivo rabbit model showing clear instances of mitochondrial uncoupling and significantly diminished tMRO2. We conclude that dual-wavelength cSFDI provides rapid, quantitative, wide-field mapping of tMRO2 that can reveal unique spatial and temporal dynamics relevant to tissue pathology and viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.