Evidence map›Paper›PMID 29575635›Full record

ArticleJournal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing2018

Biomarkers as Common Data Elements for Symptom and Self-Management Science.

Gayle G Page, Elizabeth J Corwin, Susan G Dorsey, Nancy S Redeker, Donna Jo McCloskey, Joan K Austin, Barbara J Guthrie, Shirley M Moore, Debra Barton, Miyong T Kim and 10 more

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In one paragraph

Article in Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
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  5. Trajectories of fatigue-pain-sleep disturbance symptom cluster in patients with lung cancer undergoing chemotherapy and its predictive factors: Latent class growth model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  11. Association between inflammatory cytokines and caregiving distress in family caregivers of cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Gayle G PageNu Beta, Professor and Independence Foundation Chair in Nursing Education, Johns Hopkins University School of Nursing, Baltimore, MD, USA.
Elizabeth J CorwinAlpha Epsilon, Professor and Associate Dean for Research, Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Susan G DorseyPi, Professor and Chair, Department of Pain and Translational Symptom Science, University of Maryland Baltimore, Baltimore, MD, USA.
Nancy S RedekerDelta Mu, Beatrice Renfield Term Professor of Nursing, Professor, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT.
Donna Jo McCloskeyClinical Advisor, Contractor, National Institute of Nursing Research, NIH, Bethesda, MD, USA.
Joan K AustinAlpha, Distinguished Professor Emerita, Indiana University School of Nursing, Indianapolis, IN and National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
Barbara J GuthrieProfessor, Director of the PhD Program, Northeastern University, Boston, MA, USA.
Shirley M MooreDelta Xi, Edward J. and Louise Mellen Professor of Nursing, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Debra BartonMary Lou Willard French Professor of Oncology Nursing, University of Michigan, Ann Arbor, MI, USA.
Miyong T KimEpsilon Theta, Professor, Associate Vice President for Community Health Engagement, University of Texas at Austin, Austin, TX, USA.
Sharron L DochertyIota Omicron, Associate Professor, School of Nursing; Associate Professor, Department of Pediatrics, School of Medicine, Duke University, Durham, NC, USA.
Drenna Waldrop-ValverdeAssociate Professor and Assistant Dean for Research, Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Donald E BaileyBeta Epsilon and Theta Iota, Associate Professor, Duke University, Durham, NC, USA.
Rachel F SchiffmanAlpha Chi and Eta Nu, Professor and Associate Dean for Research, College of Nursing, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Angela StarkweatherMu, Professor, University of Connecticut School of Nursing, Storrs, CT, USA.
Teresa M WardPsi-at-Large, Associate Professor, University of Washington School of Nursing, Seattle, WA, USA.
Suzanne BakkenAlpha Eta, The Alumni Professor of Nursing and Professor of Biomedical Informatics Director, Columbia University, New York, NY, USA.
Kathleen T HickeyAlpha Eta, Professor of Nursing at Columbia University Medical Center, Columbia University, New York, NY, USA.
Cynthia L RennPi, Associate Professor Department of Pain and Translational Symptom Science, University of Maryland Baltimore, Baltimore, MD, USA.
Patricia GradyTau, Director, National Institute of Nursing Research, National Institutes or Health, Bethesda, MD, USA.

Funding

SMART Center II Brain Behavior Connections in Self Management ScienceP30NR015326 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI MOORE, SHIRLEY M · 2014 to 2018
$2.8M
Pilot Projects CoreP30NR016579 · NINR · UNIVERSITY OF MARYLAND BALTIMORE · PI RESNICK, BARBARA · 2016 to 2020
$2.7M
Translational Phenotyping CoreP30NR014129 · NINR · UNIVERSITY OF MARYLAND BALTIMORE · PI GREENSPAN, JOEL D. · 2012 to 2016
$2.3M
Sleep Measurement CoreP30NR014131 · NINR · JOHNS HOPKINS UNIVERSITY · PI PAGE, GAYLE GIBONEY, SMITH, MICHAEL T · 2012 to 2015
$1.7M
Yale Center for Sleep Disturbance in Acute and Chronic ConditionsP20NR014126 · NINR · YALE UNIVERSITY · PI KRYGER, MEIR H, YAGGI, HENRY KLAR · 2012 to 2016
$1.4M
NINR NIH HHS P20 NR014126NINR NIH HHS P30 NR014129NINR NIH HHS P30 NR014131NINR NIH HHS P30 NR015326NINR NIH HHS P30 NR016579
6 · The paper itself

Abstract

purposeBiomarkers as common data elements (CDEs) are important for the characterization of biobehavioral symptoms given that once a biologic moderator or mediator is identified, biologically based strategies can be investigated for treatment efforts. Just as a symptom inventory reflects a symptom experience, a biomarker is an indicator of the symptom, though not the symptom per se. The purposes of this position paper are to (a) identify a "minimum set" of biomarkers for consideration as CDEs in symptom and self-management science, specifically biochemical biomarkers; (b) evaluate the benefits and limitations of such a limited array of biomarkers with implications for symptom science; (c) propose a strategy for the collection of the endorsed minimum set of biologic samples to be employed as CDEs for symptom science; and (d) conceptualize this minimum set of biomarkers consistent with National Institute of Nursing Research (NINR) symptoms of fatigue, depression, cognition, pain, and sleep disturbance. DESIGN AND

methodsFrom May 2016 through January 2017, a working group consisting of a subset of the Directors of the NINR Centers of Excellence funded by P20 or P30 mechanisms and NINR staff met bimonthly via telephone to develop this position paper suggesting the addition of biomarkers as CDEs. The full group of Directors reviewed drafts, provided critiques and suggestions, recommended the minimum set of biomarkers, and approved the completed document. Best practices for selecting, identifying, and using biological CDEs as well as challenges to the use of biological CDEs for symptom and self-management science are described. Current platforms for sample outcome sharing are presented. Finally, biological CDEs for symptom and self-management science are proposed along with implications for future research and use of CDEs in these areas.

findingsThe recommended minimum set of biomarker CDEs include pro- and anti-inflammatory cytokines, a hypothalamic-pituitary-adrenal axis marker, cortisol, the neuropeptide brain-derived neurotrophic factor, and DNA polymorphisms.

conclusionsIt is anticipated that this minimum set of biomarker CDEs will be refined as knowledge regarding biologic mechanisms underlying symptom and self-management science further develop. The incorporation of biological CDEs may provide insights into mechanisms of symptoms, effectiveness of proposed interventions, and applicability of chosen theoretical frameworks. Similarly, as for the previously suggested NINR CDEs for behavioral symptoms and self-management of chronic conditions, biological CDEs offer the potential for collaborative efforts that will strengthen symptom and self-management science. CLINICAL RELEVANCE: The use of biomarker CDEs in biobehavioral symptoms research will facilitate the reproducibility and generalizability of research findings and benefit symptom and self-management science.

Indexed as

Common Data ElementsBiomarkersCognition DisordersDepressionFatigueHumansPainReproducibility of ResultsSelf-ManagementSleep Wake DisordersUnited StatesBiomarkersBiomarkercommon data elementsself-managementsymptoms

Identifiers

PMID29575635
PMCPMC5945303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.