ReviewActa physiologica (Oxford, England)2018
The stressed brain of humans and rodents.
Review in Acta physiologica (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 186 citations in OpenAlex.
- Effects of Exercise Type and Sertraline on Anxiety and Social Behavior in a Female Rat Model of PTSD.Brain and behavior · 2026Article
- Sex-specific mitochondrial dysregulation and metformin response in Wilson disease.Scientific reports · 2026Article
- Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway.Nature metabolism · 2026Article
- Chronic High-Carbohydrate And High-Fat Diet-Induced Metabolic Syndrome Leads To Adrenal Dysfunction, Altered Dendritic Morphology In Limbic Regions, And Anxiety-Like Behaviors In Male Rats.Journal of molecular neuroscience : MN · 2026Article
- Acute and persistent neuroendocrine and behavioral alterations after social fear conditioning in adolescent male mice.Journal of neuroendocrinology · 2026Article
- Cortisol treatment impairs path integration and alters grid-like representations in the male human entorhinal cortex.PLoS biology · 2026Article
- Prefrontal contribution to passive coping behaviour in chronic stress and treatment by fast-acting antidepressant.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- American ginseng (Journal of ginseng research · 2026Article
- EFE-8c4, a polyamine fromFrontiers in neuroscience · 2026Article
- A Narrative Review of the Immunomodulatory Effects of ActharAdvances in therapy · 2025Review
- Effects of Noise Stress on Neuronal Activation in Rat Auditory Pathway-Related Brain Regions.Diagnostics (Basel, Switzerland) · 2025Article
- The Reassuring Absence of Acute Stress Effects on IQ Test Performance.Journal of Intelligence · 2025Article
- Novel Insights into Dietary Bioactive Compounds and Major Depressive Disorders: Evidence from Animal Studies and Future Perspectives.The Journal of nutrition · 2025Review
- Single cell resolution of neurosteroidogenesis in the murine brain: intermediary biosynthesis.The Journal of endocrinology · 2025Article
- Tauroursodeoxycholic acid mitigates depression-like behavior and hippocampal neuronal damage in a corticosterone model of female mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Stk24 deficiency causes disrupted hippocampal neurogenesis and anxiety-like behavior in mice.Communications biology · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Evaluating sex and line differences in successive negative contrast and ethanol consumption using alcohol preferring and high alcohol drinking rats.Alcohol, clinical & experimental research · 2025Article
- Neuroimmune modulatory effects of the NLRP3 inflammasome: the role of sex and living environment in brain affecting conditions.Frontiers in immunology · 2025Review
- Non-Invasive Monitoring of Corticosterone Levels in Mouse Urine with Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After stress, the brain is exposed to waves of stress mediators, including corticosterone (in rodents) and cortisol (in humans). Corticosteroid hormones affect neuronal physiology in two time-domains: rapid, non-genomic actions primarily via mineralocorticoid receptors; and delayed genomic effects via glucocorticoid receptors. In parallel, cognitive processing is affected by stress hormones. Directly after stress, emotional behaviour involving the amygdala is strongly facilitated with cognitively a strong emphasis on the "now" and "self," at the cost of higher cognitive processing. This enables the organism to quickly and adequately respond to the situation at hand. Several hours later, emotional circuits are dampened while functions related to the prefrontal cortex and hippocampus are promoted. This allows the individual to rationalize the stressful event and place it in the right context, which is beneficial in the long run. The brain's response to stress depends on an individual's genetic background in interaction with life events. Studies in rodents point to the possibility to prevent or reverse long-term consequences of early life adversity on cognitive processing, by normalizing the balance between the two receptor types for corticosteroid hormones at a critical moment just before the onset of puberty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.