Evidence map›Paper›PMID 29575527›Full record

ArticleJournal of cellular and molecular medicine2018

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.

Ping-Chih Hsu, Jinbai Miao, Zhen Huang, Yi-Lin Yang, Zhidong Xu, Joanna You, Yuyuan Dai, Che-Chung Yeh, Geraldine Chan, Shu Liu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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  9. An overview of the crosstalk between YAP and cGAS-STING signaling in non-small cell lung cancer: it takes two to tango.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
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  18. Clinicopathologic significance of nuclear HER4 and phospho-YAP(STherapeutic advances in medical oncology · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 3 countries.

Ping-Chih HsuDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.ORCID 0000-0003-0173-7509
Jinbai MiaoDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Zhen HuangDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Yi-Lin YangDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Zhidong XuDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Joanna YouDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Yuyuan DaiDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.ORCID 0000-0002-8545-433X
Che-Chung YehDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Geraldine ChanDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Shu LiuDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Anatoly UrismanDepartment of Pathology, University of California, San Francisco, CA, USA.
Cheng-Ta YangDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
David M JablonsDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Liang YouDepartment of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
University of California, San Francisco · USChang Gung Memorial Hospital · TW

Funding

The Role of Cul4A in Genome Stability and Cancer DevelopmentR01CA140654 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOU, LIANG · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA140654
6 · The paper itself

Abstract

Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine model. We found that metastatic NSCLC cell lines H2030-BrM3(K-ras

Indexed as

Adaptor Proteins, Signal TransducingAdenocarcinoma of LungAnimalsBrain NeoplasmsCarcinogenesisCell Line, TumorConnective Tissue Growth FactorDisease Models, AnimalDrug Resistance, NeoplasmErbB ReceptorsGene Expression Regulation, NeoplasticHumansMiceMutationPhosphoproteinsProto-Oncogene Proteins p21(ras)Adaptor Proteins, Signal TransducingCCN2 protein, humanConnective Tissue Growth FactorEGFR protein, humanErbB ReceptorsKRAS protein, humanPhosphoproteinsProto-Oncogene Proteins p21(ras)RNA, Small InterferingTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsHippo signallingK-ras mutationlung adenocarcinomametastasisyes-associated protein

Identifiers

PMID29575527
PMCPMC5980132
OpenAlexW2789574007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.